Alternative structural projections:
8-AHA-2'-O-Me-cAMP has only poor affinity towards protein kinases A and G and is thus suitable as a ligand in affinity chromatography of cAMP binding proteins that do not require an intact 2'-OH group, such as the exchange protein activated by cyclic AMP (Epac) and certain phosphodiesterases. Detailed technical information available.
| Cat. No. | A 099 |
| CAS number | [pending] |
| Purity | > 98% HPLC |
| Salt form | Free acid |
| Storage temperature | -20°C / -4°F |
| Molecular formula | C₁₇H₂₈N₇O₆P |
| Molecular weight [g/mol] | 457.4 |
| Modifications | 8-cAMP, 2'-cAMP |
| Target | Epac Activator |
| Lipophilicity | 1.69 |
| Absorption max [nm] | 273 |
| Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 17000 |
- 1. Hanke S. E., Bertinetti D., Badel A., Schweinsberg S., Genieser H.-G.Herberg F. W., N. Biotechnol., 28, 294 - 301 (2011), "Cyclic Nucleotides as Affinity Tools: Phosphorothioate cAMP Analogues Adress Specific PKA Subproteomes"
- 2. Borland G., Gupta M., Magiera M. M., Rundell C. J., Fuld S.Yarwood S. J., Mol. Pharmacol., 69, 374 - 384 (2006), "MAP1B-LC1 Enhances Activation of Rap1 by Exchange Protein Activated by Cyclic AMP (EPAC) but not Intracellular Targeting"
