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Cladribine, 2-Cl-dAdo, CdA

2- Chloro- 2'- deoxyadenosine ( Cladribine, 2-Cl-dAdo, CdA )
Cat. No.: C 028
    
CAS No.: [4291-63-8]
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Product Name Price (net) Qty
Cat. No.: C 028-100
Unit: 100 µmol / ~29 mg
$100.00
Adenosine deaminase-resistant analogue with antileukemic properties, probably effective via its corresponding triphosphate. Detailed technical information available. References: Wang et al., J. Biol. Chem., 268, 22847 - 22852 (1993).; Beutler, Semin. Hematol., 31, 40 - 45 (1994).
This compound is also part of the Ko-Libri compound library (K 001)
Cat. No. C 028
CAS number [4291-63-8]
Purity > 97% HPLC
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₂ClN₅O₃
Molecular weight [g/mol] 285,7
Absorption max [nm] 263
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 14000
  • 1. Leoni L. M., Chao Q., Cottam H. B., Genini D., Rosenbach M., Carrera C. J., Budihardjo I., Wang X.Carson D. A., Proc. Natl. Acad. Sci. USA, 95, 9567 - 9571 (1998), "Induction of an Apoptotic Program in Cell-free Extracts by 2-Chloro-2'-deoxyadenosine 5'-triphosphate and Cytochrome C"
  • 2. Coomber D. W. J., O'Sullivan W. J.Gero A. M., Int. J. Parasitol., 24, 357 - 365 (1994), "Adenosine Analogues as Antimetabolites against Plasmodium Falciparum Malaria"
  • 3. Beutler E., Semin. Hematol., 31, 40 - 45 (1994), "New Chemotherapeutic Agent: 2-Chlorodeoxyadenosine"
  • 4. Wang L., Karlsson A., Arner E. S. J.Eriksson S., J. Biol. Chem., 268, 22847 - 22852 (1993), "Substrate Specificity of Mitochondrial 2'-Deoxyguanosine Kinase. Efficient Phosphorylation of 2-Chlorodeoxyadenosine"