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Guanosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( cGMP-AM )
Highly membrane-permeant prodrug form of the second messenger cyclic GMP
Cat. No.: G 002
CAS No.: [164007-71-0]
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Cat. No.: G 002-01
Unit: 1 µmol / ~0.4 mg
Membrane-permeant precursor of the second messenger cyclic GMP (Cat. No. G 001). Metabolic activation by esterases releases the polar active analogue which is trapped inside the cell. In contrast to other membrane-permeant and PDE-resistant cGMP analogues, cGMP-AM yields a transient increase (pulse) of cGMP. Especially suitable for external triggering of cGMP-regulated phosphodiesterases (PDE II, III & V) where most cGMP analogues are not accepted. Detailed technical information available. Reference: Schwede et al., Bioorg. Med. Chem. Lett., 10, 571 - 573 (2000). Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.
Cat. No. G 002
CAS number [164007-71-0]
Purity > 95% HPLC for mixture of isomers
Storage temperature -20°C / -4°F
Molecular formula C₁₃H₁₆N₅O₉P
Molecular weight [g/mol] 417,3
Target PKG (cGK) Activator
Absorption max [nm] 252
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 13500