0 Items - $0.00
Categories
A to Z

cCMP-AM

Cytidine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( cCMP-AM )
Highly membrane-permeant prodrug form of the second messenger cyclic CMP
Cat. No.: C 067
    
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: C 067-01
Unit: 1 µmol / ~0.4 mg
$165.00
Membrane-permeant, metabolically activatable prodrug form of the potential further second messenger cyclic CMP (Cat. No. C 001). After permeation and metabolic activation by esterases the polar cCMP is released which is trapped inside the cell and subsequently metabolized quickly, resulting in a pulse-type signal. Detailed technical information available. Reference: Beckert et al., Biochem. Biophys. Res. Commun., 451, 497 - 502 (2014).
Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.
Cat. No. C 067
CAS number [pending]
Purity > 95% HPLC
Storage temperature -20°C / -4°F
Molecular formula C₁₂H₁₆N₃O₉P
Molecular weight [g/mol] 377,2
Absorption max [nm] 270
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 9000
  • 1. Wolter S., Kloth C., Golombek M., Dittmar F., Försterling L.Seifert R., Biochem. Pharmacol., 98, 119 - 131 (2015), "cCMP Causes Caspase-dependent Apotosis in Mouse Lymphoma Cell Lines"
  • 2. Beckert U., Grundmann M., Wolter S., Schwede F., Rehmann H., Kaever V., Kostenis E.Seifert R., Biochem. Biophys. Res. Commun., 451, 497 - 502 (2014), "cNMP-AMs Mimic and Dissect Bacterial Nucleotidyl Cyclase Toxin Effects"