0 Items - $0.00
Categories
A to Z

Alternative structural projections:

cAMP

Adenosine- 3', 5'- cyclic monophosphate ( cAMP ), sodium salt
Second messenger
Cat. No.: A 001 S
    
CAS No.: [37839-81-9]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: A 001-500 S
Unit: 500 µmol / ~176 mg
$49.00
For other salt forms please inquire. The second messenger cyclic AMP activates protein kinase A, cAMP-gated ion channels, HCN channels, the Epac receptor (cAMP-GEF), the CAP protein and some other target receptors. It is metabolized rapidly by cyclic nucleotide-dependent phosphodiesterases. Detailed technical information available.
Cat. No. A 001 S
CAS number [37839-81-9]
Purity > 99% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₁N₅O₆P · Na
Molecular weight [g/mol] 351,2
Target PKA (cAK) Activator
Lipophilicity 1.09
Absorption max [nm] 259
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 15000
  • 1. Bähre H., Hartwig C., Munder A., Wolter S., Stelzer T., Schirmer B., Beckert U., Frank D. W., Tümmler B., Kaever V.Seifert R., Biochem. Biophys. Res. Commun., 460, 909 - 914 (2015), "cCMP and cUMP Occur in Vivo"
  • 2. Lolicato M., Bucchi A., Arrigoni C., Zucca S., Nardini M., Schroeder I., Simmons K., Aquila M., DiFrancesco D., Bolognesi M., Schwede F., Kashin D., Fishwick C. W. G., Johnson A. P., Thiel G.Moroni A., Nat. Chem. Biol., 10, 457 - 462 (2014), "Cyclic Dinucleotides bind the C-linker of HCN4 to Control Channel cAMP Responsiveness"
  • 3. Beste K. Y., Spangler C. M., Burhenne H., Koch K.-W., Shen Y., Tang W.-J., Kaever V.Seifert R., PLoS ONE, 8, 0 - 0 (2013), "Nucleotidyl Cyclase Activity of Particulate Guanylyl Cyclase A: Comparison with Particulate Guanylyl Cyclases E and F, Soluble Guanylyl Cyclase and Bacterial Adenylyl Cyclases Cyaa and Edema Factor"
  • 4. Beckert U., Aw W. Y., Burhenne H., Fösterling L., Kaever V., Timmons L.Seifert R., PLoS ONE, 8, 0 - 0 (2013), "The Receptor-Bound Guanylyl Cyclase DAF-11 is the Mediator of Hydrogen Peroxide-Induced cGMP Increase in Caenorhabditis Elegans"
  • 5. Oeckl P.Ferger B., J. Neurosci. Methods, 203, 338 - 343 (2012), "Simultaneous LC-MS/MS Analysis of the Biomarkers cAMP and cGMP in Plasma, CSF and Brain Tissue"
  • 6. Zong X., Krause S., Chen C.-C., Krüger J., Gruner C., Cao-Ehlker X., Fenske S., Wahl-Schott C.Biel M., J. Biol. Chem., 287, 26506 - 26512 (2012), "Regulation of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Activity by cCMP"
  • 7. Gomelsky M., Mol. Microbiol., 79, 562 - 565 (2011), "cAMP, c-di-GMP, c-di-AMP and now cGMP: Bacteria use Them All!"
  • 8. Marden J. N., Dong Q., Roychowdhury S., Berleman J. E.Bauer C. E., Mol. Microbiol., 79, 600 - 615 (2011), "Cyclic GMP Controls Rhodospirillum Centenum Cyst Development"
  • 9. Osborne B. W., Wu J., McFarland C., Nickl C. K., Sankaran B., Casteel D. E., Woods V. L., Kornev A. P., Taylor S. S.Dostmann W. R. G., Structure, 19, 1317 - 1327 (2011), "Crystal Structure of cGMP-Dependent Protein Kinase Reveals Novel Site of Interchain Communication"
  • 10. Reinecke D., Burhenne H., Sandner P., Kaever V.Seifert R., FEBS Lett., 585, 3259 - 3262 (2011), "Human Cyclic Nucleotide Phosphodiesterases Possess a Much Broader Substrate-Specificity than Previously Appreciated"
  • 11. Werner K., Schwede F., Genieser H.-G., Geiger J.Butt E., Naunyn Schmiedebergs Arch. Pharmacol., 384, 169 - 176 (2011), "Quantification of cAMP and cGMP Analogs in Intact Cells: Pitfalls in Enzyme Immunoassays for Cyclic Nucleotides"
  • 12. Jäger R., Schwede F., Genieser H.-G., Koesling D.Russwurm M., Br. J. Pharmacol., 161, 1645 - 1660 (2010), "Activation of PDE2 and PDE5 cy Specific GAF Ligands: Delayed Activation of PDE5"
  • 13. Desch M., Schinner E., Kees F., Hofmann F., Seifert R.Schlossmann J., FEBS Lett., 584, 3979 - 3984 (2010), "Cyclic Cytidine 3',5'-Monophosphate (cCMP) Signals via cGMP Kinase I"
  • 14. Göttle M., Dove S., Kees F., Schlossmann J., Geduhn J., König B., Shen Y., Tang W.-J., Kaever V.Seifert R., Biochemistry, 49, 5494 - 5503 (2010), "Cytidylyl and Uridylyl Cyclase Activity of Bacillus anthracis Edema Factor and Bordetella pertussis CyaA"
  • 15. Bertinetti D., Schweinsberg S., Hanke S. E., Schwede F., Bertinetti O., Drewianka S., Genieser H.-G.Herberg F. W., BMC Chem Biol, 9, 0 - 0 (2009), "Chemical tools selectively target components of the PKA system"
  • 16. Sager G.Ravna A. W., Mini Rev. Med. Chem., 9, 1009 - 1013 (2009), "Cellular Efflux of cAMP and cGMP - a Question about Selectivity"
  • 17. Matthiesen K.Nielsen J., Biochem. J., 423, 401 - 409 (2009), "Binding of Cyclic Nucleotides to Phosphodiesterase 10A and 11A GAF Domains Does Not Stimulate Catalytic Activity"
  • 18. Pesavento C.Hengge R., Curr. Opin. Microbiol., 12, 170 - 176 (2009), "Bacterial Nucleotide-based Second Messengers"
  • 19. Harper S. M., Wienk H., Wechselberger R. W., Bos J. L., Boelens R.Rehmann H., J. Biol. Chem., 283, 6501 - 6508 (2008), "Structural Dynamics in the Activation of EPAC"
  • 20. Schweinsberg S., Moll D., Burghardt N. C., Hahnefeld C., Schwede F., Zimmermann B., Drewianka S., Werner L., Kleinjung F., Genieser H.-G., Schuchhardt J.Herberg F. W., Proteomics, 8, 1212 - 1220 (2008), "Systematic interpretation of cyclic nucleotide binding studies using KinetXBase"
  • 21. Goraya T. A., Masada N., Ciruela A., Willoughby D., Clynes M. A.Cooper D. M. F., Cell. Signal., 20, 359 - 374 (2008), "Kinetic Properties of Ca2+/calmodulin-dependent Phosphodiesterase Isoforms Dictate Intracellular cAMP Dynamics in Response to Elevation of cytosolic Ca2+"
  • 22. Poppe H., Rybalkin S. D., Rehmann H., Hinds T. R., Tang X.-B., Christensen A. E., Schwede F., Genieser H.-G., Bos J. L., Doeskeland S. O., Beavo J. A.Butt E., Nature Methods, 5, 277 - 278 (2008), "Cyclic Nucleotide Analogs as Probes of Signaling Pathways"
  • 23. Holz G. G., Chepurny O. G.Schwede F., Cell. Signal., 20, 10 - 20 (2008), "Epac-selective cAMP Analogs: New Tools with which to Evaluate the Signal Transduction Properties of cAMP-regulated Guanine Nucleotide Exchange Factors"
  • 24. Das R., Mazhab-Jafari M. T., Chowdhury S., SilDas S., Selvaratnam R.Melacini G., Am. Soc. Biochem. Mol. Biol., 283, 19691 - 19703 (2008), "Entrophy Driven cAMP-Dependent Allosteric Control of Inhibitory Interactions in Epac"
  • 25. Herget S., Lohse M. J.Nikolaev V. O., Cell Signal., 20, 1423 - 1431 (2008), "Real-time Monitoring of Phosphodiesterase Inhibition in Intact Cells"
  • 26. Herrmann S., Stieber J.Ludwig A., Eur. J. Physiol., 454, 517 - 522 (2007), "Pathophysiology of HCN Channels"
  • 27. Tengholm A., Cell. Mol. Life Sci., 64, 382 - 385 (2007), "Cyclic AMP: swing that message!"
  • 28. Wang H., Liu Y., Hou J., Zheng M., Robinson H.Ke H., PNAS, 104, 5782 - 5787 (2007), "Structural Insight into Substrate Specifity of Phosphodiesterase 10"
  • 29. Moll D., Prinz A., Gesellchen F., Drewianka S., Zimmermann B.Herberg F. W., J. Neural. Transm., 113, 1015 - 1032 (2006), "Biomolecular Interaction Analysis in Functional Proteomics"
  • 30. Smolen P., Baxter D. A.Byrne J. H., Biophys. J., 90, 2760 - 2775 (2006), "A Model of the Roles of Essential Kinases in the Induction and Expression of Late Long-term Potentiation"
  • 31. Prieto D., Rivera L., Recio P., Rubio J. L. R., Hernandez M.Garcia-Sacristan A., J. Urol., 175, 1164 - 1170 (2006), "Role of Nitric Oxide in the Relaxation Elicited by Sildenafil in Penile Resistance Arteries"
  • 32. Song X. J., Wang Z. B., Gan Q.Walters E. T., J. Neurophysiol., 95, 479 - 492 (2006), "cAMP and cGMP Contribute to Sensory Neuron Hyperexcitability and Hyperalgesia in Rats with Dorsal Root Ganglia Compression"
  • 33. Soto I., Rosenthal J. J. C., Blagburn J. M.Blanco R. E., J. Neurochem., 96, 82 - 96 (2006), "Fibroblast Growth Factor 2 Applied to the Optic Nerve After Axotomy Up-regulates BDNF and TrkB in Ganglion Cells by Activating the ERK and PKA Signaling Pathways"
  • 34. Lokshin A., Raskovalova T., Huang X. J., Zacharia L. C., Jackson E. K.Gorelik E., Cancer Res., 66, 7758 - 7765 (2006), "Adenosine-mediated Inhibition of the Cytotoxic Activity and Cytokine Production by Activated Natural Killer Cells"
  • 35. Kang G., Chepurny O. G., Malester B., Rindler M. J., Rehmann H., Bos J. L., Schwede F., Coetzee W. A.Holz G. G., J. Physiol.-London, 573, 595 - 609 (2006), "cAMP Sensor Epac as a Determinant of ATP-sensitive Potassium Channel Activity in Human Pancreatic Beta Cells and Rat INS-1 Cells"
  • 36. Cytrynska M., Zdybicka-Barabas A.Jakubowicz T., J. Insect Physiol., 52, 744 - 753 (2006), "Studies on the Role of Protein Kinase A in Humoral Immune Response of Galleria Mellonella Larvae"
  • 37. Badhwar A., Weston A. D., Murray J. B.Mercier A. J., Peptides, 27, 1281 - 1290 (2006), "A Role for Cyclic Nucleotide Monophosphates in Synaptic Modulation by a Crayfish Neuropeptide"
  • 38. Gesellchen F., Prinz A., Zimmermann B.Herberg F. W., Eur. J. Cell Biol., 85, 663 - 672 (2006), "Quantification of cAMP Antagonist Action In Vitro and in Living Cells"
  • 39. Gambaryan S., Butt E., Tas P., Smolenski A., Allolio B.Walter U., Amer. J. Physiol.-Endocrinol. Met., 290, 423 - 433 (2006), "Regulation of Aldosterone Production From Zona Glomerulosa Cells by ANG II and cAMP: Evidence for PKA-independent Activation of CaMK by cAMP"
  • 40. Hashiguchi H., Nakazaki M., Koriyama N., Fukudome M., Aso K.Tei C., Diabetes Metab. Res. Rev., 22, 64 - 71 (2006), "Cyclic AMP/cAMP-GEF Pathway Amplifies Insulin Exocytosis Induced by Ca2+ and ATP in Rat Islet Beta-cells"
  • 41. Moreno M. J., Ball M., Andrade M. F., McDermid A.Stanimirovic D. B., Glia, 53, 845 - 857 (2006), "Insulin-Like Growth Factor Binding Protein-4 (IGFBP-4) is a Novel Anti-Angiogenic and Anti-Tumorigenic Mediator Secreted by Dibutyryl Cyclic AMP (dB-cAMP)-Differentiated Glioblastoma Cells"
  • 42. Dames P., Zimmermann B., Schmidt R., Rein J., Voss M., Schewe B., Walz B.Baumann O., Proc. Nat. Acad. Sci. USA, 103, 3926 - 3931 (2006), "cAMP Regulates Plasma Membrane Vacuolar-Type H+-ATPase Assembly and Activity in Blowfly Salivary Glands"
  • 43. Terrin A., Di Benedetto G., Pertegato V., Cheung Y. F., Baillie G., Lynch M. J., Elvassore N., Prinz A., Herberg F. W., Houslay M. D.Zaccolo M., J. Cell Biol., 175, 441 - 451 (2006), "PGE(1) Stimulation of HEK293 Cells Generates Multiple contiguous Domains with Different [cAMP]: Role of Compartmentalized Phosphodiesterases"
  • 44. Murphy M. M., Zayed M. A., Evans A., Parker C. E., Ataga K. I., Telen M. J.Parise L. V., Blood, 105, 3322 - 3329 (2005), "Role of Rap1 in Promoting Sickle Red Blood Cell Adhesion to Laminin Via BCAM/LU"
  • 45. Kamrava M., Simpkins F., Alejandro E., Michener C., Meltzer E.Kohn E. C., Oncogene, 24, 7084 - 7093 (2005), "Lysophosphatidic Acid and Endothelin-induced Proliferation of Ovarian Cancer Cell Lines is Mitigated by Neutralization of Granulin-epithelin Precursor (GEP), a Prosurvival Factor for Ovarian Cancer"
  • 46. Dimitriadis E., Stoikos C., Baca M., Fairlie W. D., McCoubrie J. E.Salamonsen L. A., J. Clin. Endocrinol. Metab., 90, 3458 - 3465 (2005), "Relaxin and Prostaglandin E-2 Regulate Interleukin 11 During Human Endometrial Stromal Cell Decidualization"
  • 47. Zhang A. H., Liu K., Wang C. X., Ma S. Y.Li Z. H., J. Mol. Structure-Theochem., 719, 149 - 152 (2005), "Theoretical Study on the Ring-opening Hydrolysis Reaction of cAMP"
  • 48. Lohmann S. M.Walter U., Frontiers Biosci., 10, 1313 - 1328 (2005), "Tracking Functions of cGMP-dependent Protein Kinase"
  • 49. Karaolis D. K. R., Rashid M. H., Chythanya R., Luo W., Hyodo M.Hayakawa Y., Antimicrob. Agents Chemother., 49, 1029 - 1038 (2005), "c-di-GMP (3'-5'-Cyclic Diguanylic Acid) Inhibits Staphylococcus Aureus Cell-Cell Interactions and Biofilm Formation"
  • 50. Genieser H.-G., Bos J. L., Christensen A. E., Doeskeland S. O., Havemann U., Manzau U., Rehmann H.Schwede F., Poster #THP016 Montreal, 12, 0 - 0 (2004), "Analogues of Cyclic AMP to Distinguish Between PKA and Epac"
  • 51. Clayton G. M., Silverman W. R., Heginbotham L.Morais-Cabral J. H., Cell, 119, 615 - 627 (2004), "Structural Basis of Ligand Activation in a Cyclic Nucleotide Regulated Potassium Channel"
  • 52. Rehmann H., Schwede F., Doeskeland S. O., Wittinghofer A.Bos J. L., J. Biol. Chem., 278, 38548 - 38556 (2003), "Ligand-mediated Activation of the cAMP-responsive Guanine Nucleotide Exchange Factor Epac"
  • 53. Christensen A. E., Selheim F., de Rooij J., Dremier S., Schwede F., Dao K. K., Martinez A., Maenhaut C., Bos J. L., Genieser H.-G.Doeskeland S. O., J. Biol. Chem., 278, 35394 - 35402 (2003), "cAMP Analog Mapping of Epac1 and cAMP-Kinase. Discriminating Analogs Demonstrate that Epac and cAMP-Kinase Act Synergistically to Promote PC-12 Cell Neurite Extension"
  • 54. Saini S. S., Gessell-Lee D. L.Peterson J. W., Inflammation, 27, 79 - 88 (2003), "The Cox-2-Specific Inhibitor Celecoxib Inhibits Adenylyl Cyclase"
  • 55. Eliasson L., Ma X. S., Renström E., Barg S., Berggren P.-O., Galvanovskis J., Gromada J., Jing X. J., Lundquist I., Salehi A., Sewing S.Rorsman P., J. Gen. Physiol., 121, 181 - 197 (2003), "SUR1 Regulates PKA-Independent cAMP-Induced Granule Priming in Mouse Pancreatic B-Cells"
  • 56. Punta M., Cavalli A., Torre V.Carloni P., Proteins., 52, 332 - 338 (2003), "Molecular Modeling Studies on CNG Channel from Bovine Retinal Rod: A Structural Model of the Cyclic Nucleotide-Binding Domain"
  • 57. Chua N. H., Ph.D.Thesis Dept. of Anatomy and Cell Biology, 0, 0 - 0 (2003), "Novel Aspects of cAMP Signaling - Cyclic AMP Analogs as Tools to Elucidate the Rules of cAMP-Kinase and Epac"
  • 58. Paik H. C., Hoffmann S. C.Egan T. M., Transplantation, 75, 439 - 444 (2003), "Pulmonary Preservation Studies: Effects on Endothelial Function and Pulmonary Adenine Nucleotides"
  • 59. Morgan E. E., Stader S. M., Hodnichak C. M., Mavrich K. E., Folkesson H. G.Maron M. B., Am. J. Physiol.-Lung. Cell. Mol. Physiol., 285, 578 - 583 (2003), "Postreceptor Defects in Alevolar Epithelial Beta-adrenergic Signaling after Prolonged Isoproterenol Infusion"
  • 60. Deng W., Parbhu-Patel A., Meyer D. J.Baker D. A., Biochem. J., 374, 559 - 565 (2003), "The Role of Two Novel Regulatory Sites in the Activation of the cGMP-dependent Protein Kinase from Plasmodium Falciparum"
  • 61. Claeysen S., Joubert L., Sebben M., Bockaert J.Dumuis A., J. Biol. Chem., 278, 699 - 702 (2003), "A Single Mutation in the 5-HT4-Receptor (5-HT4-R D100(3.32)A) Generates a G(s)-coupled Receptor Activated Exclusively by Synthetic Ligands (RASSL)"
  • 62. Kuiperij H. B., de Rooij J., Rehmann H., van Triest M., Wittinghofer A., Bos J. L.Zwartkruis F. J. T., Biochim. Biophys. Acta-Mol. Cell Res., 1593, 141 - 149 (2003), "Characterisation of PDZ-GEFs, a Family of Guanine Nucleotide Exchange Factors Specific for Rap1 and Rap2"
  • 63. Zagotta W. N., Olivier N. B., Black K. D., Young E. C., Olson R.Gouaux E., Nature, 425, 200 - 205 (2003), "Structural Basis for Modulation and Agonist Specifity of HCN Pacemaker Channels"
  • 64. Mei F. C., Qiao J., Tsygankova O. M., Meinkoth J. L., Quilliam L. A.Cheng X., J. Biol. Chem., 277, 11497 - 11504 (2002), "Differential Signaling of cyclic AMP: Opposing Effects of Exchange Protein Directly Activated by cyclic AMP and cAMP-dependent Protein Kinase on Protein Kinase B Activation"
  • 65. Martinez S. E., Wu A. Y., Glavas N. A., Tang X.-B., Turley S., Hol W. G. J.Baevo J. A., Proc. Natl. Acad. Sci. U.S.A., 99, 13260 - 13265 (2002), "The Two GAF Domains in Phosphodiesterase 2A Have Distinct Roles in Dimerization and in cGMP Binding"
  • 66. Deng W.Baker D. A., Mol. Microbiol., 44, 1141 - 1151 (2002), "A Novel Cyclic GMP-dependent Protein Kinase is Expressed in the Ring Stage of the Plasmodium Falciparum Life Cycle"
  • 67. Won H.-S., Lee T.-W., Park S.-H.Lee B.-J., J. Biochem., 277, 11450 - 11455 (2002), "Stoichiometry and Structural Effect of the Cyclic Nucleotide Binding to Cyclic AMP Receptor Protein"
  • 68. Lin S.-H., Kovac L., Chin A. J., Chin C. C. Q.Lee J. C., Biochemistry, 41, 2946 - 2955 (2002), "Ability of E. Coli Cyclic AMP Receptor Protein To Differentiate Cyclic Nucleotides: Effects of Single Site Mutations"
  • 69. Fujimoto N., Toyama A.Takeuchi H., Biopolymers, 67, 186 - 196 (2002), "Binding Modes of Cyclic AMP and Environments of Tryptophan Residues in 1:1 and 1:2 Complexes of Cyclic AMP Receptor Protein and Cyclic AMP"
  • 70. He Y. J.Karpen J. W., Biochemistry, 40, 286 - 295 (2001), "Probing the Interactions between cAMP and cGMP in Cyclic Nuleotide-Gated Channels Using Covalently Tethered Ligands"
  • 71. Roelofs J., Snippe H., Kleineidam R. G.Van Haastert P. J. M., Biochem. J., 354, 697 - 706 (2001), "Guanylate Cyclase in Dictyostelium Discoideum with the Topology of Mammalian Adenylate Cyclase"
  • 72. Boadu E., Vaskinn S., Sundkvist E., Jaeger R.Sager G., Biochem. Pharmacol., 62, 425 - 429 (2001), "Inhibition by Guanosine Cyclic Monophosphate (cGMP) Analogues of Uptake of [H-3]3', 5'-cGMP without Stimulation of ATPase Activity in Human Erythrocyte Inside-out Vesicles"
  • 73. Sabetkar M., Naseem K. M., Tullett J. M., Friebe A., Koesling D.Bruckdorfer K. R., Nitric Oxide: Biol. Chem., 5, 233 - 242 (2001), "Synergism Between Nitric Oxide and Hydrogen Peroxide in the Inhibition of Platelet Function: The Roles of Soluble Guanylyl Cyclase and Vasodilator-Stimulated Phosphoprotein"
  • 74. Ueda M., Sako Y., Tanaka T., Devreotes P. N.Yanagida T., Science, 294, 864 - 867 (2001), "Single-Molecule Analysis of Chemotactic Signaling in Dictyostelium Cells"
  • 75. Rich T. C., Tse T. E., Rohan J. G., Schaack J.Karpen J. W., J. Gen. Physiol., 118, 63 - 77 (2001), "In Vivo Assessment of Local Phosphodiesterase Activity Using Tailored Cyclic Nucleotide-gated Channels as cAMP Sensors"
  • 76. Rich T. C., Fagan K. A., Tse T. E., Schaack J., Cooper D. M. F.Karpen J. W., Proc. Natl. Acad. Sci., 98, 13049 - 13054 (2001), "A Uniform Extracellular Stimulus Triggers Distinct cAMP Signals in Different Compartments of a Simple Cell"
  • 77. Zoraghi R., Kunz S., Gong K.Seebeck T., J. Biol. Chem., 276, 11559 - 11566 (2001), "Characterization of TbPDE2A, a Novel Cyclic Nucleotide-specific Phosphodiesterase from the Protozoan Parasite Trypanosoma Brucei"
  • 78. Shalaby T., Liniger M.Seebeck T., Eur. J. Biochem., 268, 6197 - 6206 (2001), "The Regulatory Subunit of a cGMP- regulated Protein Kinase A of Trypanosoma Brucei"
  • 79. Seebeck T., Gong K. W., Kunz S., Schaub R., Shalaby T.Zoraghi R., Int. J. Parasitology, 31, 491 - 498 (2001), "cAMP Signalling in Trypanosoma Brucei"
  • 80. Communi D., Janssens R., Robaye B., Zeelis N.Boeynaems J. M., Drug Develop. Res., 52, 156 - 163 (2001), "Role of P2Y 11 Receptors in Heamatopoisis"
  • 81. Wätjen W., Benters J., Haase H., Schwede F., Jastorff B.Beyersmann D., Toxicol., 157, 167 - 175 (2001), "Zn2+ and Cd2+ Increase the cyclic GMP level in PC12 Cells by Inhibition of the cyclic Nucleotide Phosphodiesterase"
  • 82. Schwede F., Christensen A., Liauw S., Hippe T., Kopperud R. K., Jastorff B.Doeskeland S. O., Biochemistry, 39, 8803 - 8812 (2000), "8-Substituted cAMP Analogues Reveal Marked Differences in Adaptability, Hydrogen Bonding, and Charge Accomodation between Homologous Binding Sites (AI/AII and BI/BII) in cAMP Kinase I and II"
  • 83. White R. E., Kryman J. P., El-Mowafy A. M., Han G. C.Carrier G. O., Circ. Res., 86, 897 - 905 (2000), "cAMP-Dependent Vasodilators Cross-Activate the cGMP-Dependent Protein Kinase to Stimulate BKCa Channel Activity in Coronary Artery Smooth Muscle Cells"
  • 84. Vicentini G. E., Constantin J., Lopez C. H.Bracht A., Biochem. Pharmacol., 59, 1187 - 1201 (2000), "Transport of Cyclic AMP and Synthetic Analogs in the Perfused Rat Liver"
  • 85. Zaccolo M., De Giorgi F., Cho C. Y., Feng L., Knapp T., Negulescu P. A., Taylor S. S., Tsien R. Y.Pozzan T., Nature Cell Biol., 2, 25 - 29 (2000), "A Genetically Encoded, Fluorescent Indicator for Cyclic AMP in Living Cells"
  • 86. Conti M.Jin S.-L. C., Prog. Nucl. Acid Res. Mol. Biol., 63, 1 - 38 (2000), "The Molecular Biology of Cyclic Nucleotide Phosphodiesterases"
  • 87. Yoshimura H., Hisabori T., Yanagisawa S.Ohmori M., J. Biol. Chem., 275, 6241 - 6245 (2000), "Identification and Characterization of a Novel cAMP Receptor Protein in the Cyanobacterium Synechocystis sp. PCC 6803"
  • 88. Christensen A., Dao K. K., Doeskeland S. O., Schwede F., Jastorff B., Genieser H.-G., de Rooij J., Bos J. L., Rehmann H., Kraemer A.Wittinghofer A., 12th Protein Kinase Symp. NO/cGMP and Protein Kinase Signaling Bad Brückenau/Germany, 0, 0 - 0 (2000), "8-Modified cAMP Analogs give Insight into the Geometries of the cAMP Binding Sites of RI, RII and EPAC-1"
  • 89. Hagen V., Bendig J., Frings B., Wiesner B.Kaupp U. B., 12th Protein Kinase Symp. NO/cGMP and Protein Kinase Signaling Bad Brückenau/Germany, 0, 0 - 0 (2000), "Novel Coumarinylmethyl-Caged Cyclic Nucleotides: Photochemistry and Application to Cyclic Nucleotide-Gated Channels"
  • 90. Tian L. J.Shipston M. J., Endocrinology, 141, 2930 - 2937 (2000), "Characterization of Hyperpolarization-Activated Cation Currents in Mouse Anterior Pituitary, AtT20 D16 : 16 Corticotropes"
  • 91. de Rooij J., Rehmann H., van Triest M., Cool R. H., Wittinghofer A.Bos J. L., J. Biol. Chem., 275, 20829 - 20836 (2000), "Mechanism of Regulation of the Epac Family of cAMP-dependent RapGEFs"
  • 92. Schwede F., Maronde E., Genieser H.-G.Jastorff B., Pharmacol. Ther., 87, 199 - 226 (2000), "Cyclic Nucleotide Analogs as Biochemical Tools and Prospective Drugs"
  • 93. Enrich M. J. D., Villamarin J. A., Martinez J. I. R.Ibarguren I., Anal. Biochem., 285, 105 - 112 (2000), "Measurement of Adenosine 3',5'-Cyclic Monophosphate and Guanosine 3',5'-Cyclic Monophosphate in Mussel (Mytilus galloprovincialis Lmk.) by High-Performance Liquid Chromatography with Diode Array Detection"
  • 94. Frisch S. M., Nature Cell Biol., 2, 167 - 168 (2000), "cAMP Takes Control"
  • 95. Muhonen W. W.Shabb J. B., Protein Sci., 9, 2446 - 2456 (2000), "Resonant Mirror Biosensor Analysis of Type I(Alpha) cAMP-dependent Protein Kinase B Domain-Cyclic Nucleotide Interactions"
  • 96. Hahnefeld C., Diploma work Bochum Germany, 0, 0 - 0 (2000), "Untersuchungen zur Nukleotidbindung von cAMP-abhängigen Proteinkinasen"
  • 97. Li F., Gangal M., Jones J. M., Deich J., Lovett K. E., Taylor S. S.Johnson D. A., Biochemistry, 39, 15626 - 15632 (2000), "Consequences of cAMP and Catalytic-Subunit Binding on the Flexibility of the A-Kinase Regulatory Subunit"
  • 98. Vicentini G. E., Lopez C. H., Constantin J.Bracht A., Res. Commun. Mol. Pathol. P., 107, 297 - 309 (2000), "Modeling the Transformation of Exogenously Supplied cAMP in the Perfused Rat Liver"
  • 99. Liu S. L., Rao Y.Daw N., Cereb. Cortex., 13, 864 - 69 (2000), "Roles of Protein Kinase A and Protein Kinase G in Synaptic Plasticity in the Visual Cortex"
  • 100. Smith J. A., Reed R. B., Francis S. H., Grimes K.Corbin J. D., J. Biol. Chem., 275, 154 - 158 (2000), "Distinguishing the Roles of the Two Different cGMP-binding Sites for Modulating Phosphorylation of Exogenous Substrate (Heterophosphorylation) and Autophosphorylation of cGMP-dependent Protein Kinase"
  • 101. Taylor M. K.Uhler M. D., J. Biol. Chem., 275, 28053 - 28062 (2000), "The Amino-terminal Cyclic Nucleotide Binding Site of the Type II cGMP-dependent Protein Kinase is Essential for Full cyclic Nucleotide-dependent Activation"
  • 102. Tesmer J. J. G., Dessauer C. W., Sunahara R. K., Murray L. D., Johnson R. A., Gilman A. G.Sprang S. R., Biochemistry, 39, 14464 - 14471 (2000), "Molecular Basis for P-Site Inhibition of Adenylyl Cyclase"
  • 103. Ohyama T., Hackos D. H., Frings S., Hagen V., Kaupp U. B.Korenbrot J. I., J. Gen. Physiol., 116, 735 - 753 (2000), "Fraction of the Dark Current Carried by Ca2+ through cGMP-gated Ion Channels of Intact Rod and Cone Photoreceptors"
  • 104. Boadu E.Sager G., Biochim. Biophys. Acta, 1509, 467 - 474 (2000), "ATPase Activity and Transport by a cGMP Transporter in Human Erythrocyte Ghosts and Proteoliposome-reconstituted Membrane Extracts"
  • 105. Wilensky A. E., Schafe G. E.LeDoux J. E., J. Neurosci., 20, 7059 - 7066 (2000), "The Amygdala Modulates Memory Consolidation of Fear-Motivated Inhibitory Avoidance Learning but not Classical Fear Conditioning"
  • 106. Schafe G. E., Atkins C. M., Swank M. W., Bauer E. P., Sweatt J. D.LeDoux J. E., J. Neurosci., 20, 8177 - 8187 (2000), "Activation of ERK/MAP Kinase in the Amygdala is Required for Memory Consolidation of Pavlovian Fear Conditioning"
  • 107. Gardner C., Robas N., Cawkill D.Fidock M., Biochemical & Biophysical Research Communications, 272, 186 - 192 (2000), "Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase"
  • 108. Sasaki T., Kotera J., Yuasa K.Omori K., Biochemical & Biophysical Research Communications, 271, 575 - 583 (2000), "Identification of human PDE7B, a cAMP-specific phosphodiesterase"
  • 109. Hetman J. M., Soderling S. H., Glavas N. A.Baevo J. A., Proc. Natl. Acad. Sci. U.S.A., 97, 472 - 476 (2000), "Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase"
  • 110. Sunderman E. R.Zagotta W. N., J. Gen. Physiol., 113, 621 - 640 (1999), "Sequence of Events Underlying the Allosteric Transition of Rod Cyclic Nucleotide-Gated Channels"
  • 111. Sunderman E. R.Zagotta W. N., J. Gen. Physiol., 113, 601 - 619 (1999), "Mechanism of Allosteric Modulation of Rod Cyclic Nucleotide-Gated Channels"
  • 112. Nikolakaki E., Fissentzidis A., Giannakouros T.Georgatsos J. G., Mol. Cell. Biochem., 197, 117 - 128 (1999), "Purification and Characterization of a Dimer Form of the cAMP-dependent Protiein Kinase from Mouse Liver Cytosol"
  • 113. Seifert R., Scholten A., Gauss R., Mincheva A., Lichter P.Kaupp U. B., Proc. Natl. Acad. Sci. USA, 96, 9391 - 9396 (1999), "Molecular Characterization of a Slowly Gating Human Hyperpolarization-Activated Channel Predominantly Expressed in Thalamus, Heart, and Testis"
  • 114. de Rooij J., Boenink N. M., van Triest M., Cool R. H., Wittinghofer A.Bos J. L., J. Biol. Chem., 274, 38125 - 38130 (1999), "PDZ-GEF1, a Guanine Nucleotide Exchange Factor Specific for Rap1 and Rap2"
  • 115. Biel M., Ludwig A., Zong X.Hofmann F., Rev. Physiol. Biochem. Pharmacol., 136, 165 - 181 (1999), "Hyperpolarization-Activated Cation Channels: A Multi-Gene Family"
  • 116. Biel M., Zong X.Hofmann F., Adv. Second Messenger Phosphoprotein Res., 33, 231 - 250 (1999), "Cyclic Nucleotide Gated Channels"
  • 117. Biel M., Zong X., Ludwig A., Sautter A.Hofmann F., Rev. Physiol. Biochem. Pharmacol., 135, 151 - 171 (1999), "Structure and Function of Cyclic Nucleotide-Gated Channels"
  • 118. Francis S. H.Corbin J. D., Crit. Rev. Clin. Lab. Sci., 36, 275 - 328 (1999), "Cyclic Nucleotide-Dependent Protein Kinases: Intracellular Receptors for cAMP and cGMP Action"
  • 119. Hirsch J. R., Meyer M., Mägert H.-J., Forssmann W.-G., Mollerup S., Herter P., Weber G., Cermak R., Ankorina-Stark I., Schlatter E.Kruhoffer M., J. Am. Soc. Nephrol., 10, 472 - 480 (1999), "cGMP-dependent and -independent Inhibition of a K+ Conductance by Natriuretic Peptides: Molecular and Functional Studies in Human Proximal Tubule Cells"
  • 120. Tsuruhara A., Suzuki H.Tezuka T., Plant Cell Physiol., 40, 1093 - 1098 (1999), "Inhibition of the activity of NAD(P)H-dependent oxidase in pistils of Lilium longiflorum by cAMP"
  • 121. Schwede F., Genieser H.-G.Jastorff B., Cell. Mol. Biol. Lett., 4, 466 - 0 (1999), "Cyclic Nucleotide Analogs as Prospective Drugs"
  • 122. Cho-Chung Y. S., Jastorff B.Genieser H.-G., USA patent 5916, 843, 0 - 0 (1998), "Cyclic AMP Analogues, Individually and in Pairs, to Inhibit Neoplastic Cell Growth"
  • 123. Riegel J. A., Maddrell S. H. P., Farndale F. W.Caldwell F. M., J. Exp. Biol., 201, 3411 - 3418 (1998), "Stimulation of Fluid Secretion of Malpighian Tubules of Drosophila Melanogaster Meig. by Cyclic Nucleotides of Inosine, Cytidine, Thymidine and Uridine"
  • 124. de Rooij J., Zwartkruis F. J. T., Verheijen M. H. G., Cool R. H., Nijman S. M. B., Wittinghofer A.Bos J. L., Nature, 396, 474 - 477 (1998), "Epac is a Rap 1 Guanine-Nucleotide-Exchange Factor Directly Activated by Cyclic AMP"
  • 125. Cao J., Fernandez M.Villamarin J. A., Prot. Expr. Purif., 14, 418 - 424 (1998), "A Method for the Purification of cAMP-Dependent Protein Kinase Using Immunoaffinity Chromatography"
  • 126. Hebert M. C., Schwede F., Jastorff B.Cote R. H., J. Biol. Chem., 273, 5557 - 5565 (1998), "Structural Features of the Noncatalytic cGMP Binding Sites of Frog Photoreceptor Phoshodiesterase Using cGMP Analogs"
  • 127. Tasken K., Aandahl E. M., Aukrust P., Müller F., Froland S. S.Hansson V., Intl. Patent Appl. PCT, 0, 0 - 0 (1998), "Use of Immunomodulating Agents"
  • 128. Huang L. J.Taylor S. S., J. Biol. Chem., 273, 26739 - 26746 (1998), "Dissecting cAMP Binding Domain A in the R(I)Alpha Subunit of cAMP-dependent Protein Kinase"
  • 129. Forloni G., Lucca E., Angeretti N., Chiesa R.Vezzani A., J. Neurochem., 68, 319 - 327 (1997), "Neuroprotective Effect of Somatostatin on Nonapoptotic NMDA-Induced Neuronal Death - Role of Cyclic GMP"
  • 130. Anciaux K., Van Dommelen K., Willems R., Roymans D.Slegers H., FEBS Lett., 400, 75 - 79 (1997), "Inhibition of Nucleoside Diphosphate Kinase (NDPK/NM23) by cAMP Analogues"
  • 131. Lalley P. M., Pierrefiche O., Bischoff A. M.Richter D. W., J. Neurophysiol., 77, 1119 - 1131 (1997), "cAMP-Dependent Protein Kinase Modulates Expiratory Neurons In Vivo"
  • 132. Lipsius S. L.Wang Y. G., J. Mol. Cell. Cardiol., 29, 907 - 914 (1997), "Cholinergic Short-Term Conditioning and Activation of ATP-Sensitive K+ Current in Cat Atrial Myocytes"
  • 133. Jiang L., Foster F. M., Ward P., Tasevski V., Luttrell B. M.Conigrave A. D., Biochem. Biophys. Res. Commun., 236, 626 - 630 (1997), "Extracellular ATP Triggers Cyclic AMP-Dependent Differentiation of HL-60 Cells"
  • 134. Wilderman M. J.Armstead W. M., Amer. J. Phys.-Heart Circ. Phys., 41, 1350 - 1358 (1997), "Role of PACAP in the Relationship Between cAMP and Opioids in Hypoxia-Induced Pial Artery Vasodilation"
  • 135. Bonkale W. L., Cowburn R. F., Winblad B.Fastbom J., Brain Res., 763, 1 - 13 (1997), "Autoradiographic Characterization of (H-3)cGMP Binding Sites in the Rat Brain."
  • 136. Oh J. D., Del Dotto P.Chase T. N., Neurosci. Lett., 228, 5 - 8 (1997), "Protein Kinase A Inhibitor Attenuates Levodopa-Induced Motor Response Alterations in the Hemi-Parkinsonian Rat."
  • 137. Wolf F. L., Di Francesco A., Covacci V.Cittadini A., Arch. Biochem. Biophys., 344, 397 - 403 (1997), "Regulation of Magnesium Efflux from Rat Spleen Lymphocytes"
  • 138. Capece M. L.Lydic R., Amer. J. Physiol.- Regul. Integr. C., 42, 1430 - 1440 (1997), "cAMP and Protein Kinase A Modulate Cholinergic Rapid Eye Movement Sleep Generation"
  • 139. Krass J. D., Jastorff B.Genieser H.-G., Anal. Chem., 69, 2575 - 2581 (1997), "Determination of Lipophilicity by Gradient Elution High-Performance Liquid Chromatography"
  • 140. Bernabeu R., Bevilaqua L., Ardenghi P. G., Bromberg E., Schmitz P., Bianchin M., Izquierdo I.Medina J. H., Proc. Natl. Acad. Sci., 94, 7041 - 7046 (1997), "Involvement of Hippocampal cAMP/cAMP-Dependent Protein Kinase Signaling Pathways in a Late Memory Consolidation Phase of Aversively Motivated Learning in Rats"
  • 141. Chu D.-M., Corbin J. D., Grimes K. A.Francis S. H., J. Biol. Chem., 272, 31922 - 31928 (1997), "Activation by Cyclic GMP Binding Causes an Apparent Conformational Change in cGMP-Dependent Protein Kinase"
  • 142. Bos J. L., Franke B., M'Rabet L., Reedquist K.Zwartkruis F., FEBS Lett., 410, 59 - 62 (1997), "In Search of a Function for the Ras-like GTPase Rap1"
  • 143. Poteet-Smith C. E., Shabb J. B., Francis S. H.Corbin J. D., J. Biol. Chem., 272, 379 - 388 (1997), "Identification of Critical Determinants for Autoinhibition in the Pseudosubstrate Region of Type I(Alpha) cAMP-dependent Protein Kinase"
  • 144. Gibson R. M.Taylor S. S., J. Biol. Chem., 272, 31998 - 32005 (1997), "Dissecting the Cooperative Reassociation of the Regulatory and Catalytic Subunits of cAMP-dependent Protein Kinase"
  • 145. Paces V.Smrz J., FEBS Lett., 31, 343 - 344 (1997), "On the Specificity of Cyclic AMP Action in Escherichia Coli"
  • 146. Passner J. M.Steitz T. A., Proc. Natl. Acad. Sci. USA, 94, 2843 - 2847 (1997), "The Structure of a CAP-DNA Complex Having Two cAMP Molecules Bound to Each Monomer"
  • 147. Hatton C. J.Peers C., Pflugers Arch.- Eur. J. Physiol., 433, 129 - 135 (1996), "Hypoxic Inhibition of K+ Currents in Isolated Rat Type I Carotid Body Cells - Evidence Against the Involvement of Cyclic Nucleotides"
  • 148. Takei T., Takano K., Yasufukutakano J., Fujita T.Yamashita N., Amer. J. Physiol.-Endocrin. Met., 34, 801 - 807 (1996), "Enhancement of CA2+Currents by GHRH and its Relation to PKA and CA2+ (1) in Human GH-Secreting Adenoma Cells"
  • 149. Butt E.Walter U., in 'Platelets: A Practical Approach' IRL Press Oxford, 0, 259 - 278 (1996), "Cyclic Nucleotides: Measurement and Function"
  • 150. Finn J. T., Grunwald M. E.Yau K. W., Annu. Rev. Physiol., 58, 395 - 426 (1996), "Cyclic Nucleotide-Gated Ion Channels: An Extended Family With Diverse Functions"
  • 151. Schwede F., Ph.D. Thesis, 0, 0 - 0 (1996), "Synthese und Eigenschaften ausgewählter Analoga von cGMP und ihr Einsatz in der biologischen Forschung"
  • 152. Huq I., Dostmann W. R. G.Oegreid D., Biochem. J., 316, 337 - 343 (1996), "Isoleucine 368 is Involved in Low-Affinity Binding of N6-Modified cAMP Analogues to Site B of the Regulatory Subunit of cAMP-Dependent Protein Kinase I"
  • 153. Newton R. P., in Proceedings of the Phytochemical Society of Europe (R.P.Newton/T.J.Walton Clarendon Press Oxford, 0, 158 - 181 (1996), "11. Mass Spectrometric Analysis of Cyclic Nucleotides and Related Enzymes"
  • 154. Zorn M., Fladmark K. E., Oegreid D., Jastorff B., Doeskeland S. O.Dostmann W. R. G., FEBS Lett., 362, 291 - 294 (1995), "Ala 335 is Essential for High-affinity cAMP-binding of Both Sites A and B of cAMP-dependent Protein Kinase Type I"
  • 155. Butt E., Beltman J., Becker D. E., Jensen G. S., Rybalkin S. D., Jastorff B.Baevo J. A., Mol. Pharmacol., 47, 340 - 347 (1995), "Characterization of Cyclic Nucleotide Phosphodiesterases with Cyclic AMP Analogs: Topology of the Catalytic Site and Comparison with Other Cyclic AMP-Binding Proteins"
  • 156. Burgering B. M. T.Bos J. L., TIBS, 20, 18 - 22 (1995), "Regulation of Ras-Mediated Signalling: More than one Way to Skin a Cat"
  • 157. Reymond C. D., Schaap P., Veron M.Williams J. G., Experientia, 51, 1166 - 1174 (1995), "Dual Role of cAMP during Dictyostelium Development"
  • 158. Scott S.-P.Tanaka J. C., Biochemistry, 34, 2338 - 2347 (1995), "Molecular Interactions of 3',5'-Cyclic Purine Analogues with the Binding Site of Retinal Rod Ion Channels"
  • 159. Defagot C.Zubin P., Biol. Res., 27, 193 - 197 (1994), "Preparation, Production and Functional Characterization of Anti cAMP and cGMP Antibodies"
  • 160. Biel M., Zong X., Distler M., Bosse E., Klugbauer N., Murakami M., Flockerzi V.Hofmann F., Proc. Natl. Acad. Sci. USA, 91, 3505 - 3509 (1994), "Another Member of the Cyclic Nucleotide-Gated Channel Family, Expressed in Testis, Kidney, and Heart"
  • 161. Bologa C., Muresan S., Liauw S., Iwitzki F.Chiriac A., Anal. Univ. Timisoara, 2, 27 - 36 (1993), "Quantitative Structure-Activity Study by the MTD-Method for cAMP-Derivatives with Large Substituents in Positions 2 and 8"
  • 162. Tezuka T., Hiratsuka S.Takahashi S. Y., Plant Cell Physiol., 34, 955 - 958 (1993), "Promotion of the Growth of Self-incompatible Pollen Tubes in Lily by cAMP"
  • 163. Fischer E. H., Angew. Chem., 105, 1181 - 1188 (1993), "Protein-Phosphorylierung und Zellregulation II (Nobel-Vortrag)"
  • 164. Naß N., Colling C., Cramer M., Genieser H.-G., Butt E., Winkler E., Jaenicke L.Jastorff B., Biochem. J., 285, 129 - 136 (1992), "Mapping of the Epitope/Paratope Interactions of a Monoclonal Antibody Directed Against Adenosine- 3', 5'- monophosphate"
  • 165. Butt E., Nolte C., Schulz S., Beltman J., Beavo J. A., Jastorff B.Walter U., Biochem. Pharmacol., 43, 2591 - 2600 (1992), "Analysis of the Functional Role of cGMP-dependent Protein Kinase in Intact Human Platelets Using a Specific Activator 8-pCPT-cGMP"
  • 166. Szücs K., Sagi G.Vereb G., Int. J. Biochem., 24, 915 - 921 (1992), "Effect of Some New cAMP Analogs on cAMP-Dependent Protein Kinase Isoenzymes"
  • 167. Van Ments-Cohen M., Genieser H.-G., Jastorff B., Van Haastert P. J. M.Schaap P., FEMS Microbiol. Lett., 82, 9 - 14 (1991), "Kinetics and Nucleotide Specificity of a Surface cAMP Binding Site in Dictyostelium discoideum, which is not Down-regulated by cAMP"
  • 168. Sandberg M., Butt E., Nolte C., Fischer L., Halbrügge M., Beltmann J., Jahnsen T., Genieser H.-G., Jastorff B.Walter U., Biochem. J., 279, 521 - 527 (1991), "Characterization of Sp- 5, 6- dichloro-1-ß-D-ribofuranosylbenzimidazole- 3',5'- monophosphorothioate (Sp-5,6-DCl-cBIMPS) as a Potent and Specific Activator of cyclic AMP- dependent Protein Kinase in Cell Extracts and Intact Cells"
  • 169. Worby A., Mensah L. M.Murray K. J., Biochem. Pharmacol., 42, 1318 - 1321 (1991), "Identification of the Novel Rat Liver IBMX-insensitive Phosphodiesterase as a Non-specific Phosphodiesterase Capable of Hydrolysing cCMP"
  • 170. Shabb J. B., Buzzeo B. D., Ng L.Corbin J. D., J. Biol. Chem., 266, 24320 - 24326 (1991), "Mutating Protein Kinase cAMP-binding Sites into cGMP-binding Sites"
  • 171. Setzer W. N.Bentrude W. G., J. Org. Chem., 56, 7212 - 7218 (1991), "Solid-State Conformations of Nucleosid Cyclic 3',5'-Monophosphate Derivatives. Effects of Substituents on Phosphorus on Ring Geometries and n/sigma* Orbital Interactions"
  • 172. Van Lookeren Campagne M. M., Diaz F. V., Jastorff B., Winkler E., Genieser H.-G.Kessin R. W., J. Biol. Chem., 265, 5847 - 5854 (1990), "Characterization of the Yeast Low Km cAMP- Phosphodiesterase With cAMP Analogues"
  • 173. Butt E., van Bemmelen M., Fischer L., Walter U.Jastorff B., FEBS Lett., 263, 47 - 50 (1990), "Inhibition of cGMP- dependent Protein Kinase by Rp-Guanosine 3', 5'-monophosphorothioates"
  • 174. Houge G., Steinberg R. A., Oegreid D.Doeskeland S. O., J. Biol. Chem., 265, 19507 - 19516 (1990), "The Interaction of Catalytic Subunit (C) of cAMP-dependent Protein Kinase with Regulatory Subunit (RI) Having One or Both cAMP Sites Occupied"
  • 175. Manganiello V. C., Tanaka T.Murashima S., Cyclic Nucleotide Phosphodiesterases: Structure M.D. Houslay ed. - Wiley Interscience Chichester UK, 0, 61 - 82 (1990), "Cyclic GMP-Stimulated Cyclic Nucleotide Phosphodiesterases"
  • 176. Manganiello V. C., Smith C. J., Degerman E.Belfrage P., Cyclic Nucleotide Phosphodiesterases: Structure; M.D. Houslay ed. - Wiley Interscience Chichester UK, 0, 87 - 116 (1990), "Cyclic GMP-Inhibited Cyclic Nucelotide Phosphodiesterases"
  • 177. Newton R. P., Salih S. G.Khan J. A., Cyclic Nucleotide Phosphodiesterases: Structure M.D. Houslay ed., Wiley Interscience Chichester UK, 17, 141 - 159 (1990), "Cyclic CMP-Specific Phosphodiesterase Activity"
  • 178. Barsony J.Marx S. J., Proc. Natl. Acad. Sci., 87, 1188 - 1192 (1990), "Immunocytology on Microwave-fixed Cells Reveals Rapid and Agonist-specific Changes in Subcellular Accumulation Patterns or cAMP or cGMP"
  • 179. Wolfe L., Corbin J. D.Francis S. H., J. Biol. Chem., 264, 7734 - 7741 (1989), "Characterization of a Novel Isozyme of cGMP-dependent Protein Kinase From Bovine Aorta"
  • 180. Oegreid D., Ekanger R., Suva R. H., Miller J. P.Doeskeland S. O., Eur. J. Biochem., 181, 19 - 31 (1989), "Comparison of the Two Classes of Binding Sites ( A and B ) of Type I and Type II Cyclic AMP-dependent Protein Kinases Using Cyclic Nucleotide Analogs"
  • 181. Tanaka J. C., Eccleston J. F.Furman R. E., Biochemistry, 28, 2776 - 2784 (1989), "Photoreceptor Channel Activation by Nucleotide Derivatives"
  • 182. Caretta A.Saibil H., J. Cell Biol., 108, 1517 - 1522 (1989), "Visualization of Cyclic Nucleotide Binding Sites in the Vertebrate Retina by Fluorescence Microscopy"
  • 183. Shanahan M. F.Edwards B. M., Endocrinology, 125, 1074 - 1081 (1989), "Stimulation of Glucose Transport in Rat Cardiac Myocytes by Guanosine-3',5'-Cyclic-Monophosphate"
  • 184. Janistyn B., Phytochemistry, 28, 329 - 331 (1989), "cAMP promoted protein phosphorylation of dialysed coconut milk"
  • 185. Techel D.Braumann T., J. Chromatography, 483, 427 - 430 (1989), "Determination of Cyclic Nucleotide Phosphodiesterase Activity in Cellular Systems by Ion-pair Reversed-phase Liquid Chromatography"
  • 186. Thalhofer H. P., Starz W., Daum G., Wurster B., Harris B. G.Hofer H. W., Arch. Biochem. Biophys., 271, 471 - 478 (1989), "Purification and Properties of the Cyclic 3', 5'-AMP-Binding Protein from the Muscle of the Nematode Ascaris suum"
  • 187. Oegreid D., Doeskeland S. O., Gorman K. B.Steinberg R. A., J. Biol. Chem., 263, 17397 - 17404 (1988), "Mutations That Prevent Cyclic Nucleotide Binding to Binding Sites A or B of Type I Cyclic AMP- dependent Protein Kinase"
  • 188. Beebe S. J., Beasley-Leach A.Corbin J. D., Methods Enzymol., 159, 531 - 540 (1988), "cAMP Analogs Used to Study Low-km, Hormone-sensitive Phosphodiesterase"
  • 189. Gronenborn A. M., Sandulache R., Gärtner S.Clore G. M., Biochem. J., 253, 801 - 807 (1988), "Mutations in the Cyclic AMP Binding Site of the Cyclic AMP Receptor Protein of Escherichia coli"
  • 190. Fayolle C.Fillion G., J. Chromatography, 426, 177 - 182 (1988), "Reversed-phase Liquid Chromatographic Determination of Cyclic Adenosine 3', 5'-monophosphate in Rat Brain Cortex"
  • 191. Johnson J. D., Walters J. D.Mills J. S., Anal. Biochem., 162, 291 - 295 (1987), "A Continous Fluorescence Assay for Cyclic Nucleotide Phosphodiesterase Hydrolysis of Cyclic GMP"
  • 192. Braumann T., Erneux C., Petridis G., Stohrer W.-D.Jastorff B., Biochim. Biophys. Acta, 871, 199 - 206 (1986), "Hydrolysis of Cyclic Nucleotides by a Purified cGMP- stimulated Phosphodiesterase: Structural Requirements for Hydrolysis"
  • 193. Scheinman S. J., Stec W. J.Coulson R., Miner. Electrolyte Metab., 11, 85 - 90 (1985), "Effects of (Sp)- and (Rp)-Adenosine Cyclic 3',5' Phosphorothioates on Electrolyte Excretion by the Isolated Perfused Rat Kidney"
  • 194. Kesbeke F., Baraniak J., Bulgakov R., Jastorff B., Morr M., Petridis G., Stec W. J., Seela F.Van Haastert P. J. M., Eur. J. Biochem., 151, 179 - 186 (1985), "Cyclic Nucleotide Specificity of the Activator and Catalytic Sites of a cGMP-stimulated cGMP Phosphodiesterase from Dictyostelium discoideum."
  • 195. Ebright R. H., Le Grice S. F. J., Miller J. P.Krakow J. S., J. Mol. Biol., 182, 91 - 107 (1985), "Analogs of Cyclic AMP that Elicit the Biochemically Defined Conformational Change in Catabolite Gene Activator Protein (CAP) but do not Stimulate Binding to DNA"
  • 196. Braumann T.Jastorff B., J. Chromatography, 329, 321 - 330 (1985), "Physico-chemical Characterization of Cyclic Nucleotides by Reversed-Phase High-Performance Liquid Chromatography. I. Cation Binding in the Mobile Phase"
  • 197. Scholübbers H.-G., Van Knippenberg P. H., Baraniak J., Stec W. J., Morr M.Jastorff B., Eur. J. Biochem., 138, 101 - 109 (1984), "Investigations on Stimulation of Lac Transciption in Vivo in Escherichia Coli by cAMP Analogs"
  • 198. de Crombrugghe B., Busby S.Buc H., Science, 224, 831 - 838 (1984), "Cyclic AMP Receptor Protein: Role in Transcription Activation"
  • 199. Oegreid D., Doeskeland S. O.Miller J. P., J. Biol. Chem., 258, 1041 - 1049 (1983), "Evidence That Cyclic Nucleotides Activating Rabbit Muscle Protein Kinase I Interact with Both Types of cAMP Binding Sites Associated with the Enzyme"
  • 200. Robinson-Steiner A. M.Corbin J. D., J. Biol. Chem., 258, 1032 - 1040 (1983), "Probable Involvement of Both Intrachain cAMP Binding Sites in Activation of Protein Kinase"
  • 201. Gronenborn A. M.Clore G. M., Biochemistry, 21, 4040 - 4048 (1982), "Proton Nuclear Magnetic Resonance Studies on Cyclic Nucleotide Binding to the Escherichia coli Adenosine Cyclic 3',5'- Phosphate Receptor Protein"
  • 202. de Wit R. J. W., Arents J. C.Van Driel R., FEBS Lett., 145, 150 - 154 (1982), "Ligand Binding Properties of the Cytoplasmic cAMP-Binding Protein of Dictyostelium discoideum"
  • 203. de Wit R. J. W., Hoppe J., Stec W. J., Baraniak J.Jastorff B., Eur. J. Biochem., 122, 95 - 99 (1982), "Interaction of cAMP Derivatives with the 'Stable' cAMP-Binding Site in the cAMP-Dependent Protein Kinase Type I"
  • 204. Varughese K. I., Lu C. T.Kartha G., J. Am. Chem. Soc., 104, 3398 - 3401 (1982), "The Crystal and Molecular Structure of Cyclic Adenosine 3', 5'- Monophosphate Sodium Salt, Monoclinic Form"
  • 205. Donnelly T. E.Barron B., Biochim. Biophys. Acta, 657, 168 - 178 (1981), "Effects of Divalent Metals on the Specificity of Inhibitors of the Cyclic Nucleotide Phosphodiesterases from Bovine Heart"
  • 206. Erneux C., Couchie D., Dumont J. E., Baraniak J., Stec W. J., Garcia Abbad E., Petridis G.Jastorff B., Eur. J. Biochem., 115, 503 - 510 (1981), "Specificity of cyclic GMP Activation of a Multi-substrate Cyclic Nucleotide Phosphodiesterase from Rat Liver"
  • 207. Robberecht P., Deschodt-Lanckman M., Woussen-Colle M.-C., De Neef P., Camus J. C.Christophe J., Mol. Pharmacol., 17, 268 - 274 (1980), "Butyryl Derivatives of Cyclic GMP Interfere With the Biological and the Immunological Properties of the Pancreozymin-Gastrin Family of Peptides"
  • 208. Rannels S. R.Corbin J. D., J. Biol. Chem., 255, 7085 - 7088 (1980), "Two Different Intrachain cAMP Binding Sites of cAMP-Dependent Protein Kinases"
  • 209. Francis S. H., Lincoln T. M.Corbin J. D., J. Biol. Chem., 255, 620 - 626 (1980), "Characterization of a Novel cGMP Binding Protein from Rat Lung"
  • 210. Czarnecki J., Geahlen R.Haley B. E., Methods Enzymol., 56, 642 - 653 (1979), "Synthesis and Use of Azido Photoaffinity Analogs of Adenine and Guanine Nucleotides"
  • 211. Jastorff B., Hoppe J.Morr M., Eur. J. Biochem., 101, 555 - 561 (1979), "A Model for the Chemical Interactions of Adenosine 3':5'- Monophosphate with the R Subunit of Protein Kinase Type I"
  • 212. Niles R. M., Ludwig K. W.Makarski J. S., J. Natl. Cancer Inst., 63, 909 - 911 (1979), "Differential Growth Inhibition in Two Human Carcinoma Cell Lines by Cyclic Adenosine 5'-Monophosphate Analogs"
  • 213. Jastorff B., Hoppe J., Mato J. M.Konijn T. M., in Molecular Mechanisms of Biological Recognition Ed.) Elsevier North-Holland Biomedical Press, 0, 107 - 117 (1979), "Ligand Analogs - A Tool for the Elucidation of Protein-Ligand Interactions. Model System: cAMP"
  • 214. Nishikori K.Maeno H., J. Biol. Chem., 254, 6099 - 6109 (1979), "Close Relationship between Adenosine 3',5'-Monophosphate-dependent Endogenous Phosphorylation of a Specific Protein and Stimulation of Calcium Uptake in Rat Uterine Microsomes"
  • 215. Cheng Y.-C.Bloch A., J. Biol. Chem., 253, 2522 - 2524 (1978), "Demonstration, in Leukemia L-1210 Cells, of a Phosphodiesterase Acting on 3':5'-Cyclic CMP but not on 3':5'-Cyclic AMP or 3':5'-Cyclic GMP"
  • 216. Meyer R. B., Stone T. E.Heinzel F. P., J. Heterocycl. Chem., 15, 1511 - 1512 (1978), "Direct Sulfhydrolysis of Cyclic AMP: A One-Step Synthesis of the Cyclic Ribonucleotide of 6-Mercaptopurine ( 1 )."
  • 217. Narimatsu A.Taira N., Eur. J. Pharmacol., 42, 71 - 78 (1977), "Positive Dromotropic Effect of Dibutyryl Cyclic Adenosine 3',5'-Monophosphate on the Atrioventricular Node"
  • 218. O'Neill J. P., Li A. P.Hsie A. W., BBA, 497, 35 - 45 (1977), "Action of Cyclic Nucleotide Analogues in Chinese Hamster Ovary Cells"
  • 219. Dworkin M.Keller K. H., J. Biol. Chem., 252, 864 - 865 (1977), "Solubility and Diffusion Coefficient of Adenosine 3':5'- Monophosphate"
  • 220. Free C. A.Paik V. S., Endo, 100, 1287 - 1293 (1977), "Adrenal Stereoidogenic Actions of Cyclic Nucleotide Derivatives in the Rat"
  • 221. Eilen E.Krakow J. S., Biochim. Biophys. Acta, 493, 115 - 121 (1977), "Effects of Cyclic Nucleotides on the Conformational States of the alpha Core of the Cyclic AMP Receptor Protein"
  • 222. Bevers M. M., van Rijn J.van Wijk R., FEBS Letters, 72, 275 - 278 (1976), "A Comparative Study on the Metabolism of N6, O2'-Dibutyryl Adenosine 3', 5'-Monophosphate in Various Rat Hepatoma Cell Lines in Culture"
  • 223. Miller J. P., Boswell K. H., Mian A. M., Meyer R. B., Robins R. K.Khwaja T. A., Biochemistry, 15, 217 - 223 (1976), "2'- Derivatives of Guanosine and Inosine Cyclic 3', 5'- Phosphates. Synthesis, Enzymic Activity, and the Effect of 8- Substituents"
  • 224. Sasaki Y., Suzuki N., Sowa T., Nozawa R.Yokota T., Biochemistry, 15, 1408 - 1413 (1976), "Effects of 8-Substituted Adenosine 3',5'-monophosphate Derivatives on High Km Phosphodiesterase Activity"
  • 225. Naka T.Honjo M., Chem. Pharm. Bull., 24, 2052 - 2056 (1976), "Synthesis of 8-Carbamoyl- and 8-Carboxyadenosine 3', 5'-Cyclic Phosphates"
  • 226. Khwaja T. A., Boswell K. H., Robins R. K.Miller J. P., Biochemistry, 14, 4238 - 4244 (1975), "8-Substituted Derivatives of Adenosine 3', 5'- Cyclic Phosphate Require an Unsubstituted 2'- Hydroxyl Group in the Ribo Configuration for Biological Activity"
  • 227. Siggins G. R.Henriksen S. J., Science, 189, 559 - 560 (1975), "Analogs of Cyclic Adenosine Monophosphate: Correlation of Inhibition of Purkinje Neurons with Protein Kinase Activation"
  • 228. Meyer R. B., Uno H., Shuman D. A., Robins R. K., Simon L. N.Miller J. P., J. Cyclic Nucl. Res., 1, 159 - 167 (1975), "The Synthesis of 2,6-Disubstituted-9-beta-D-Ribofuranosylpurine Cyclic 3',5'-Phosphates and the Selectivity of cAMP and cGMP-specific Enzymes to Substituents in These Positions"
  • 229. Garbers D. L., Suddath J. L.Hardman J. G., BBA, 377, 174 - 185 (1975), "Enzymatic Formation of Inosine 3', 5'-Monophosphate and of 2'-Deoxyguanosine 3', 5'-Monophosphate - Inosinate and Deoxyguanylate Cyclase Activity"
  • 230. Fazakerley G. V., Russell J. C.Wolfe M. A., J. Chem. Soc. Chem. Commun., 13, 527 - 0 (1975), "Conformation of the Gadolinium Complexes of Adenosine 3',5' Cyclic Monophosphoric Acid and Inosine 3',5' Cyclic Monophosphoric Acid"
  • 231. Michal G., Mühlegger K., Nelboeck M., Thiessen C.Weimann G., Pharmacol. Res. Commun., 6, 203 - 252 (1974), "Cyclophosphates VI. Cyclophosphates as Substrates and Effectors of Phosphodiesterase"
  • 232. Jastorff B.Freist W., Bioorg. Chem., 3, 103 - 113 (1974), "Synthesis and Biological Activities of cyclic AMP Analogs Modified in the 1, 2 and 2'- Positions"
  • 233. Imai S., Otorii T., Takeda K., Katano Y.Horii D., Jpn. J. Pharmacol., 24, 499 - 510 (1974), "Effects of Cyclic AMP and Dibutyryl Cyclic AMP on the Heart and Coronary Circulation"
  • 234. Bloch A., Biochem. Biophys. Res. Commun., 58, 652 - 659 (1974), "Cytidine 3',5'-Monophosphate (Cyclic CMP) - Isolation from Extracts of Leukemia L-1210 Cells"
  • 235. Antonoff R. S.Ferguson J. J., J. Biol. Chem., 249, 3319 - 3321 (1974), "Photoaffinity Labeling with Cyclic Nucleotides"
  • 236. Fikus M., Kwast-Welfeld J., Kazimierczuk Z.Shugar D., Acta Biochim. Polon., 21, 465 - 473 (1974), "Biochemical Studies on Some New Analogues of Adenosine- 3', 5'- Cyclic Phosphate, Including Isoguanosine- 3', 5'- Cyclic Phosphate"
  • 237. Kuo J. F., Miyamoto E.Reyes P. L., Biochem. Pharmacol., 23, 2011 - 2021 (1974), "Activation and Dissociation of Adenosine 3', 5'- Monophosphate-dependent and Guanosine 3', 5'- monophosphate-dependent Protein Kinases by Various Cyclic Nucleotide Analogs"
  • 238. Maguire M. H., Penglis-Caredes F.Gough G. R., Experientia, 30, 922 - 924 (1974), "Effects of the 3', 5'- Cyclic Phosphates of 2- Methylthioadenosine, 2- Chloroadenosine and Adenosine on Platelet Aggregation"
  • 239. Nelböck M., Michal G.Weimann G., Pure Appl. Chem., 35, 411 - 437 (1973), "Analogues of Cyclic AMP and their Physiological Response"
  • 240. Ferguson D. R.Twite B. R., Brit. J. Pharmac., 49, 288 - 292 (1973), "Inhibition by Diuretics of Cyclic 3', 5'-AMP-dependent Protein Kinase from Toad Bladder Epithelium"
  • 241. Szabo M.Burke G., Biochim. Biophys. Acta, 264, 289 - 299 (1972), "Uptake and Metabolism of 3',5'- Cyclic Adenosine Monophosphate and N6, O2'-Dibutyryl 3',5'- Cyclic Adenosine Monophosphate in Isolated Bovine Thyroid Cells"
  • 242. Anderson W. B., Perlman R. L.Pastan I., J. Biol. Chem., 247, 2717 - 2722 (1972), "Effect of Adenosine 3', 5'- Monophosphate Analogues on the Activity of the Cyclic Adenosine 3', 5'- Monophosphate Receptor in Escherichia coli"
  • 243. Sundaralingam M.Abola J., Nature New Biol., 235, 244 - 245 (1972), "Molecular Conformation of Adenosine 3',5'-Monophosphonate Monohydrate"
  • 244. Sundaralingam M.Abola J., J. Amer. Chem. Soc., 94, 5070 - 5076 (1972), "Stereochemistry of Nucleic Acids and Their Constituents. XXVII. The Crystal Structure of 5'-Methyleneadenosine 3',5'-Cyclic Monophosphonate Monohydrate, a Biologically Active Analog of the Secondary Hormonal Messenger Cyclic Adenosine 3',5'-Monophosphate."
  • 245. Steiner A. L., Parker C. W.Kipnis D. M., J. Biol. Chem., 247, 1106 - 1113 (1972), "Radioimmunoassay for Cyclic Nucleotides. I. Preparation of Antibodies and Iodinated Cyclic Nucleotides"
  • 246. Bauer R. J., Swiatek K. R., Robins R. K.Simon L. N., Biochem. Biophys. Res. Commun., 45, 526 - 531 (1971), "Adenosine 3',5'- cyclic Monophosphate Derivatives II. Biological Activity of Some 8-Substituted Analogs"
  • 247. Jost J.-P.Rickenberg H. V., Annu. Rev. Biochem., 40, 741 - 774 (1971), "Cyclic AMP"
  • 248. Du Plooy M., Michal G., Weimann G., Nelboeck M.Paoletti R., Biochim. Biophys. Acta, 230, 30 - 39 (1971), "Cyclophosphates I. Effect of Various Cyclophosphates on Phosphorylase b Kinase Activation"
  • 249. Blecher M., Ro'Ane J. T.Flynn P. D., Arch. Biochem. Biophys., 142, 351 - 362 (1971), "Biological Roles for 3',5'- Cyclic Nucleotides. I. Lipolytic Agents in isolated Rat Epididymal Adipose Cells and Substrates for Adipose Tissue Phosphodiesterase"
  • 250. Free C. A., Chasin M., Paik V. S.Hess S. M., Biochemistry, 10, 3785 - 3789 (1971), "Steroidogenic and Lipolytic Activities of 8-Substituted Derivatives of Cyclic 3',5'-Adenosine Monophosphate"
  • 251. Posternak T.Cehovic G., Ann. New York Acad. Sci., 185, 42 - 49 (1971), "Derivatives and Analogues of Cyclic Nucleotides"
  • 252. Gibson D. W., Beer M.Barrnett R. J., Biochemistry, 10, 3669 - 3679 (1971), "Gold (III) Complexes of Adenine Nucleotides"
  • 253. Blecher M., Ro'Ane J. T.Flynn P. D., Biochem. Pharmacol., 20, 249 - 251 (1971), "Biochemical Activities of Tubercidin 3', 5'-cyclic Monophosphate in Rat Epididymal Adipose Tissue"
  • 254. Michal G., Nelböck M.Weimann G., Z. Anal. Chem., 252, 189 - 193 (1970), "Cyclophosphate III. Spaltung Verschiedener Cyclophosphate durch Phosphodiesterase aus Herz und Fettgewebe"
  • 255. Levine R. A., Clin. Pharm. Therap., 11, 238 - 243 (1970), "Effects of Exogenous Adenosine 3',5'-monophosphate in Man"
  • 256. Swislocki N. I., Anal. Biochem., 38, 260 - 269 (1970), "Decomposition of Dibutyryl Cyclic AMP in Aqueous Buffers"
  • 257. Kuo J. F.Greengard P., Biochem. Biophys. Res. Commun., 40, 1032 - 1038 (1970), "Stimulation of Adenosine 3', 5'- Monophosphate- dependent and Guanosine 3', 5'- Monophosphate- dependent Protein Kinase by some Analogs of Adenosine 3', 5'- Monophosphate"
  • 258. Drummond G. I.Powell C. A., Mol. Pharmacol., 6, 24 - 30 (1970), "Analogues of Adenosine 3', 5'-Cyclic Phosphate as Activators of Phosphorylase b Kinase and as Substrates for Cyclic 3', 5'-Nucleotide Phosphodiesterase"
  • 259. Kuo J. F., Krueger B. K., Sanes J. R.Greengard P., Biochim. Biophys. Acta, 212, 79 - 91 (1970), "Cyclic Nucleotide-dependent Protein Kinases - V. Preparation and Properties of Adenosine-3', 5'-Monophosphate-dependent Protein Kinase from Various Bovine Tissues"
  • 260. Ishiyama J., Yokotsuka T.Saito N., United States Patent 3842, 630, 0 - 0 (1968), "Production of 3',5'- Cyclic Adenylic Acid With Micro-Organisms"
  • 261. Henion W. F., Sutherland E. W.Posternak T. H., Biochim. Biophys. Acta, 148, 106 - 113 (1967), "Effects of Derivatives of Adenosine 3', 5'-Phosphate on Liver Slices and Intact Animals"
  • 262. Falbriard J.-G., Posternak T.Sutherland E. W., BBA, 148, 99 - 105 (1967), "Preparation of Derivatives of Adenosine 3', 5'-Phosphate"
  • 263. Hirata M.Hayaishi O., Biochem. Biophys. Res. Commun., 24, 360 - 364 (1966), "Enzymic Formation of Deoxyadenosine 3', 5'- Phosphate"
  • 264. Hardman J. G.Sutherland E. W., J. Biol. Chem., 240, 3704 - 3705 (1965), "A cyclic 3', 5'- Nucleotide Phosphodiesterase from Heart with Specificity for Uridine 3', 5'- Phosphate"
  • 265. Posternak T., Sutherland E. W.Henion W. F., BBA, 65, 558 - 560 (1962), "Derivatives of Cyclic 3',5'- Adenosine Monophosphate"

Show more