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cADPR

Cyclic adenosine diphosphate ribose ( cADPR ), ammonium salt
Second messenger
Cat. No.: C 005
    
CAS No.: [119340-53-3]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: C 005-005
Unit: 0.5 µmol / ~270 µg
$68.00

For other salt forms or analogues please inquire. Modulates calcium release in many biological systems including plants. Second messenger, e.g. for glucose-induced insulin release. Detailed technical information and references available. References: Lee et al., J. Biol. Chem., 264, 1608 - 1615 (1989); Dammermann & Guse, J. Biol. Chem., 280, 21394 - 21399 (2005).

Cat. No. C 005
CAS number [119340-53-3]
Purity > 98% HPLC
Salt form Ammonium
Storage temperature -70°C / -94°F
Molecular formula C₁₅H₂₁N₅O₁₃P₂ (free acid)
Molecular weight [g/mol] 541,3 (free acid)
Absorption max [nm] 260
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 12400
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  • 2. Lange I., Yamamoto S., Partida-Sanchez S., Mori Y., Fleig A.Penner R., Sci. Signal., 2, 0 - 0 (2009), "TRPM2 Functions as a Lysosomal Ca2+-Release Channel in Beta Cells"
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  • 8. Billington R. A., Bellomo E. A., Floriddia E. M., Erriquez J., Distasi C.Genazzani A. A., FASEB J., 20, 521 - 523 (2006), "A Transport Mechanism for NAADP in a Rat Basophilic Cell Line"
  • 9. Guse A. H., Gu X., Zhang L., Weber K., Krämer E., Yang Z., Jin H., Li Q., Carrier L.Zhang l., J. Biol. Chem., 280, 15952 - 15959 (2005), "A Minimal Structural Analogue of Cyclic ADP-ribose - Synthesis and Calcium Release Activity in Mammalian Cells"
  • 10. Guse A. H., FEBS J., 272, 4590 - 4597 (2005), "Second Messenger Function and the Structure-activity Relationship of Cyclic Adenosine Diphosphoribose (cADPR)"
  • 11. Dammermann W.Guse A. H., J. Biol. Chem., 280, 21394 - 21399 (2005), "Functional Ryanodine Receptor Expression is Required for NAADP-mediated Local Ca2+ Signaling in T-Lymphocytes"
  • 12. Aarhus R., Graeff R. M., Dickey D. M., Walseth T. F.Lee H. C., J. Biol. Chem., 270, 30327 - 30333 (1995), "ADP-ribosyl Cyclase and CD38 Catalyze the Synthesis of a Calcium-mobilizing Metabolite from NADP+"
  • 13. Chini E. N., Beers K. W.Dousa T. P., J. Biol. Chem., 270, 3216 - 3223 (1995), "Nicotinate Adenine Dinucleotide Phosphate (NAADP) Triggers a Specific Calcium Release System in Urchin Eggs"
  • 14. Lee H. C., Walseth T. F., Bratt G. T., Hayes R. N.Clapper D. L., J. Biol. Chem., 264, 1608 - 1615 (1989), "Structural Determination of a Cyclic Metabolite of NAD+ with Intracellular Ca2+ -mobilizing Activity"