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c-diIMP

Cyclic diinosine monophosphate ( c-diIMP ), sodium salt
Cat. No.: C 105
    
CAS No.: [79940-41-3]
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Product Name Price (net) Qty
Cat. No.: C 105-01
Unit: 1 µmol / ~0.7 mg
$235.00
For other salt forms or analogues please inquire. Analogue of the bacterial second messengers c-diAMP (Cat. No. C 088) and c-diGMP (Cat. No. C 057), respectively. Potential adjuvant for mucosal vaccination. Detailed technical information available. References: Ross et al., J. Biol. Chem., 265, 18933 - 18943 (1990); Libanova et al., Vaccine, 28, 2249 - 2258 (2010).
Cat. No. C 105
CAS number [79940-41-3]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₀H₂₂N₈O₁₄P₂ (free acid)
Molecular weight [g/mol] 660,4 (free acid)
Absorption max [nm] 249
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 21600
  • 1. Sureka K., Choi P. H., Precit M., Delince M., Pensinger D. A., Huynh T. N., Jurado A. R., Goo Y. A., Sadilek M., Iavarone A. T., Sauer J. D., Tong L.Woodward J. J., Cell, 158, 1389 - 1401 (2014), "The Cyclic Dinucleotide c-diAMP is an Allosteric Regulator of Metabolic Enzyme Function"
  • 2. Shanahan C. A., Gaffney B. L., Jones R. A.Strobel S. A., Biochemistry, 52, 365 - 377 (2013), "Identification of c-di-GMP Derivatives Resistant to an EAL Domain Phosphodiesterase"
  • 3. Dubensky T. W., Kanne D. B.Leong M. L., Ther. Adv. Vaccines, 1, 131 - 143 (2013), "Rationale, Progress and Development of Vaccines Utilizing STING-activating Cyclic Dinucleotide Adjuvants"
  • 4. Ching S. M., Tan W. J., Chua K. L.Lam Y., Bioorg. Med. Chem., 18, 6657 - 6665 (2010), "Synthesis of Cyclic Di-nucleotidic Acid as Potential Inhibitors Targeting Diguanylate Cyclase"
  • 5. Libanova R., Ebensen T., Schulze K., Bruhn D., Nörder M., Yevsa T., Morr M.Guzman C. A., Vaccine, 28, 2249 - 2258 (2010), "The Member of the cyclic Di-Nucleotide Family bis-(3', 5')-cyclic Dimeric Inosine Monophosphate Exerts Potent Activity as Mucosal Adjuvant"
  • 6. Ross P., Mayer R., Weinhouse H., Amikam D., Huggirat Y., Benziman M., de Vroom E., Fidder A., de Paus P., Sliedregt L. A. J. M., van der Marel G. A.van Boom J. H., J. Biol. Chem., 265, 18933 - 18943 (1990), "The Cyclic Diguanylic Acid Regulatory System of Cellulose Synthesis in Acetobacter xylinum. Chemical Synthesis and Biological Activity of a Nucleotide Dimer, Trimer, and Phosphothioate Derivatives"