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Alternative structural projections:

c[8-Biotin-11-G(2',5')pA(3',5')p]

Cyclic (8- (2- (6- [biotinyl]aminohexanoyl)aminoethylthio)guanosine- (2' −> 5')- monophosphate- adenosine- (3' −> 5')- monophosphate) ( c[8-Biotin-11-G(2',5')pA(3',5')p] / c[8-[Biotin]-AET-G(2',5')pA(3',5')p] ), sodium salt

Biotinylated analogue of the metazoan second messenger 2',3'-cGAMP
Cat. No.: C 176
    
CAS No.: [pending]
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Product Name Price (net) Qty
Cat. No.: C 176-001
Unit: 0.1 µmol / ~0.1 mg
$286.00
For other salt forms please inquire. Biotinylated analogue of the metazoan cyclic dinucleotide second messenger c[G(2',5')pA(3',5')p] (aka cGAMP(2'-5') or 2'3'-cGAMP, Cat. No. C 161) in which the biotin label is attached to position 8 of the guanine nucleobase via a 11 atom spacer. Potential tracer in immunoassays, for affinity chromatography or pull-down assays. c[G(2',5')pA(3',5')p] was found to be the metazoan second messenger produced by the mammalian innate immune DNA sensor cGAMP synthase (cGAS). Detailed technical information available. References for c[G(2',5')pA(3',5')p]: Gao et al., Cell, 153, 1094 - 1107 (2013); Ablasser et al., Nature, 498, 380- 384 (2013); Zhang et al., Mol. Cell, 51, 226 - 235 (2013) Diner et al., Cell Rep., 3, 1355 - 1361 (2013)
Cat. No. C 176
CAS number [pending]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₃₈H₅₄N₁₄O₁₆P₂S₂ (free acid)
Molecular weight [g/mol] 1089 (free acid)
Absorption max [nm] 266
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 23500
  • 1. Bridgeman A., Maelfait J., Davenne T., Partridge T., Peng Y., Mayer A., Dong T., Kaever V., Borrow P.Rehwinkel J., Science, 349, 1228 - 1232 (2015), "Viruses Transfer the Antiviral Second Messenger cGAMP Between Cells"