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BCMCM-caged 8-Br-cAMP

[6, 7- Bis(carboxymethoxy)coumarin- 4- yl]methyl- 8- bromoadenosine- 3', 5'- cyclic monophosphate ( BCMCM-caged 8-Br-cAMP )
Caged cyclic AMP, releasing a fluorescent coumarin upon uncaging
Cat. No.: B 018
    
CAS No.: [370091-64-8]
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Product Name Price (net) Qty
Cat. No.: B 018-001
Unit: 0.1 µmol / ~76 µg
$160.00
Equatorial isomer. BCMCM-caged 8-Br-cAMP is an only weakly fluorescent, caged precursor of 8-bromo cyclic cAMP, which upon irradiation, releases both 8-Br-cAMP and a fluorescent coumarin analogue. Excellent solubility in water or buffers. Detailed technical information available. Reference: Hagen et al., Angew. Chem. Int. Ed., 40, 1045 - 1048 (2001).
Cat. No. B 018
Patent Information Protected by patent DE 100 21 256.5 and foreign equivalents
CAS number [370091-64-8]
Purity > 98% HPLC
Storage temperature -20°C / -4°F
Light-sensitive True
Molecular formula C₂₄H₂₁BrN₅O₁₄P x 2.5 H₂O
Molecular weight [g/mol] 759,4
Modifications 8-cAMP
Target PKA (cAK) Activator
Absorption max [nm] 346
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 10300
  • 1. Hagen V., Benndorf K.Kaupp U. B., aus: Dynamic Studies in Biology - Phototriggers R. Givens) Wiley-VCH Verlag Weinheim, 0, 0 - 0 (2005), "Photochemical Release of Second Messengers - Caged Cyclic Nucleotides"
  • 2. Kaupp U. B.Seifert R., Physiol. Rev., 82, 769 - 824 (2002), "Cyclic Nucleotide-Gated Ion Channels"
  • 3. Hagen V., Kaupp U. B., Bendig J.Wiesner B., Deutsche Offenlegungsschrift of 20.04.2000, 0, 0 - 0 (2000), "Neue, photolabile Cumarinylmethylester von cyclischen Nucleotiden, Verfahren zu deren Herstellung und ihre Verwendung"