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Ap₅A

P¹, P⁵- Di- (adenosine- 5')- pentaphosphate ( Ap₅A ), sodium salt
Cat. No.: D 055
    
CAS No.: [4097-04-5]
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Product Name Price (net) Qty
Cat. No.: D 055-005
Unit: 0.5 µmol / ~0.5 mg
$155.00
For other salt forms or analogues please inquire. Symmetrical dinucleoside polyphosphate with long phosphate chain. Detailed technical information and references available. References: Lewis et al., Br. J. Pharmacol., 129, 124 - 130 (2000); Pintor et al., J. Pharmacol. Exp. Ther., 304, 342 - 348 (2003); Gomez-Villafuertes et al., J. Pharmacol. Exp. Ther., 308, 1148 - 1157 (2004).
Cat. No. D 055
CAS number [4097-04-5]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₀H₂₉N₁₀O₂₂P₅ (free acid)
Molecular weight [g/mol] 916,4 (free acid)
Absorption max [nm] 259
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 27000
  • 1. Guzman-Aranguez A., Díez l. M., Martín-Gil A., Gualix J., Miras-Portugal M. T.Pintor J., Exp. Eye. Res., 101, 49 - 55 (2012), "Effect of Diinosine Polyphosphates on Intraocular Pressure in Normotensive Rabbits"
  • 2. Gómez-Villafuertes R., Sánchez-Nogueiro J., Marín-García P.Miras-Potrtugal M. T., Neurochem. Int., 50, 628 - 641 (2007), "Existence of High and Low Affinity Dinucleotides Pentaphosphate-induced Calcium Responses in Individual Synaptic Terminals and Lack of Correlation with the Distribution of P2X1-7 Subunits"
  • 3. Gomez-Villafuertes R., Pintor J., Gualix J.Miras-Portugal M. T., J. Pharmacol. Exp. Ther., 308, 1148 - 1157 (2004), "GABA Modulates Presynaptic Signalling Mediated by Dinucleotides on Rat Synaptic Terminals"
  • 4. Pintor J., Peral A., Peláez T., Martín S.Hoyle C. H. V., J. Pharmacol. Exp. Ther., 304, 342 - 348 (2003), "Presence of Diadenosine Polyphosphates in the Aqueous Humor: Their Effect on Intraocular Pressure"
  • 5. Haghiac M., Pojoga L. H.Hildermann R. H., Cell Signal., 13, 145 - 150 (2001), "Studies on the effect of diadenlyated nucleotides on calcium mobilization and prostacyclin synthesis in bovine aortic endothelial cells"
  • 6. Lewis C. J., Gitterman D. P., Schlüter H.Evans R. J., Br. J. Pharmacol., 129, 124 - 130 (2000), "Effects of Diadenosine Polyphosphates (Ap(n)As) and Adenosine Polyphospho Guanosines (Ap(n)Gs) on Rat Mesenteric Artery P2X Receptor Ion Channels"
  • 7. Chavan A. J., Haley B. E., Volkin D. B., Marfia K. E., Verticelli A. M., Bruner M. W., Draper J. P., Burke C. J.Middaugh C. R., Biochemistry, 33, 7193 - 7202 (1994), "Interaction of Nucleotides with Acidic Fibroblast Growth Factor (FGF- 1)"
  • 8. Mayo K. H., Mvele O. M.Puri R. N., FEBS Lett., 265, 97 - 100 (1990), "Proton Magnetic Resonance Spectroscopic Analysis of Diadenosine 5´,5´´´-polyphosphates"