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Ap₃A

P¹, P³- Di- (adenosine- 5')- triphosphate ( Ap₃A ), sodium salt
Cat. No.: D 117
    
CAS No.: [5959-90-0]
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Product Name Price (net) Qty
Cat. No.: D 117-005
Unit: 0.5 µmol / ~0.4 mg
$80.00
For other salt forms or analogues please inquire. Induces proliferation of vascular smooth muscle cells (Bobbert et al., Biochem. Pharmacol., 75, 1966 - 1973 (2008)) and exhibits vasoactivity. Detailed technical information and references available. References: Luo et al., FASEB J., 13, 695 - 705 (1999); Lewis et al., Br. J. Pharmacol., 129, 124 - 130 (2000);  Pintor et al., J. Pharmacol. Exp. Ther., 304, 342 - 348 (2003); Conant et al., Vasc.  Pharmacol., 48, 157 - 164 (2008).
Cat. No. D 117
CAS number [5959-90-0]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₀H₂₇N₁₀O₁₆P₃ (free acid)
Molecular weight [g/mol] 756,4 (free acid)
Absorption max [nm] 259
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 27000
  • 1. Guzman-Aranguez A., Díez l. M., Martín-Gil A., Gualix J., Miras-Portugal M. T.Pintor J., Exp. Eye. Res., 101, 49 - 55 (2012), "Effect of Diinosine Polyphosphates on Intraocular Pressure in Normotensive Rabbits"
  • 2. Bobbert P., Schlüter H., Schultheiss H. P.Reusch H. P., Biochem. Pharmacol., 75, 1966 - 1973 (2008), "Diadenosine Polyphosphates Ap3A and Ap4A, but not Ap5A or Ap6A, Induce Proliferation of Vascular Smooth Muscle Cells"
  • 3. Conant A. R., Theologou T., Dihmis W. C.Simpson A. W., Vascul. Pharmacol., 48, 157 - 164 (2008), "Diadenosine Polyphosphates are Selective Vasoconstrictors in Human Coronary Artery Bypass Grafts"
  • 4. Pintor J., Peral A., Peláez T., Martín S.Hoyle C. H. V., J. Pharmacol. Exp. Ther., 304, 342 - 348 (2003), "Presence of Diadenosine Polyphosphates in the Aqueous Humor: Their Effect on Intraocular Pressure"
  • 5. Haghiac M., Pojoga L. H.Hildermann R. H., Cell Signal., 13, 145 - 150 (2001), "Studies on the effect of diadenlyated nucleotides on calcium mobilization and prostacyclin synthesis in bovine aortic endothelial cells"
  • 6. Lewis C. J., Gitterman D. P., Schlüter H.Evans R. J., Br. J. Pharmacol., 129, 124 - 130 (2000), "Effects of Diadenosine Polyphosphates (Ap(n)As) and Adenosine Polyphospho Guanosines (Ap(n)Gs) on Rat Mesenteric Artery P2X Receptor Ion Channels"
  • 7. Luo J., Jankowski J., Knobloch M., van der Giet M., Gardanis K., Russ T., Vahlensieck U., Neumann J., Schmitz W., Tepel M., Deng M. C., Zidek W.Schlüter H., FASEB J., 13, 695 - 705 (1999), "Identification and Characterization of Diadenosine 5',5''-P1,P2 -Diphosphate and Diadenosine 5',5''-P1,P3-Triphosphate in Human Myocardial Tissue"
  • 8. Chavan A. J., Haley B. E., Volkin D. B., Marfia K. E., Verticelli A. M., Bruner M. W., Draper J. P., Burke C. J.Middaugh C. R., Biochemistry, 33, 7193 - 7202 (1994), "Interaction of Nucleotides with Acidic Fibroblast Growth Factor (FGF- 1)"
  • 9. Mayo K. H., Mvele O. M.Puri R. N., FEBS Lett., 265, 97 - 100 (1990), "Proton Magnetic Resonance Spectroscopic Analysis of Diadenosine 5´,5´´´-polyphosphates"