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Ap₄A

P¹, P⁴- Di- (adenosine- 5')- tetraphosphate ( Ap₄A ), sodium salt
Cat. No.: D 115
    
CAS No.: [5542-28-9]
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Product Name Price (net) Qty
Cat. No.: D 115-01
Unit: 1 µmol
$150.00
For other salt forms or analogues please inquire. Induces proliferation of vascular smooth muscle cells (Bobbert et al., Biochem. Pharmacol., 75, 1966 - 1973 (2008)), apoptosis in human cultured cells (Vartanian et al., FEBS Lett., 456, 175 - 180 (1999)) and exhibits vasoconstrictor activity (Lewis et al., Br. J. Pharmacol., 129, 124 - 130 (2000)). Detailed technical information and references available.
Cat. No. D 115
CAS number [5542-28-9]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₀H₂₈N₁₀O₁₉P₄ (free acid)
Molecular weight [g/mol] 836,4 (free acid)
Absorption max [nm] 259
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 27000
  • 1. Guzman-Aranguez A., Díez l. M., Martín-Gil A., Gualix J., Miras-Portugal M. T.Pintor J., Exp. Eye. Res., 101, 49 - 55 (2012), "Effect of Diinosine Polyphosphates on Intraocular Pressure in Normotensive Rabbits"
  • 2. Bobbert P., Schlüter H., Schultheiss H. P.Reusch H. P., Biochem. Pharmacol., 75, 1966 - 1973 (2008), "Diadenosine Polyphosphates Ap3A and Ap4A, but not Ap5A or Ap6A, Induce Proliferation of Vascular Smooth Muscle Cells"
  • 3. Gómez-Villafuertes R., Sánchez-Nogueiro J., Marín-García P.Miras-Potrtugal M. T., Neurochem. Int., 50, 628 - 641 (2007), "Existence of High and Low Affinity Dinucleotides Pentaphosphate-induced Calcium Responses in Individual Synaptic Terminals and Lack of Correlation with the Distribution of P2X1-7 Subunits"
  • 4. Swennen E. L., Bast A.Dagnelie P. C., Biochem. Biophys. Res. Commun., 348, 1194 - 1199 (2006), "Purinergic Receptors Involved in the Immunomodulatory Effects of ATP in Human Blood"
  • 5. Guranowski A., Acta Biochim. Pol., 50, 947 - 972 (2003), "Analogs of Diadenosine Tetraphosphate (Ap4A)"
  • 6. Haghiac M., Pojoga L. H.Hildermann R. H., Cell Signal., 13, 145 - 150 (2001), "Studies on the effect of diadenlyated nucleotides on calcium mobilization and prostacyclin synthesis in bovine aortic endothelial cells"
  • 7. Lewis C. J., Gitterman D. P., Schlüter H.Evans R. J., Br. J. Pharmacol., 129, 124 - 130 (2000), "Effects of Diadenosine Polyphosphates (Ap(n)As) and Adenosine Polyphospho Guanosines (Ap(n)Gs) on Rat Mesenteric Artery P2X Receptor Ion Channels"
  • 8. Vartanian A., Alexandrov I., Prudowski I., McLennan A.Kisselev L., FEBS Lett., 456, 175 - 180 (1999), "Ap4A Induces Apoptosis in Human Cultured Cells"
  • 9. Chavan A. J., Haley B. E., Volkin D. B., Marfia K. E., Verticelli A. M., Bruner M. W., Draper J. P., Burke C. J.Middaugh C. R., Biochemistry, 33, 7193 - 7202 (1994), "Interaction of Nucleotides with Acidic Fibroblast Growth Factor (FGF- 1)"
  • 10. Mayo K. H., Mvele O. M.Puri R. N., FEBS Lett., 265, 97 - 100 (1990), "Proton Magnetic Resonance Spectroscopic Analysis of Diadenosine 5´,5´´´-polyphosphates"