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AICAR / Acadesine / Z- riboside

5- Aminoimidazole- 4- carboxamide- 1- β- D- ribofuranoside ( AICAR / Acadesine / Z-riboside )
Cat. No.: A 103
    
CAS No.: [2627-69-2]
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Product Name Price (net) Qty
Cat. No.: A 103-10
Unit: 10 µmol / ~2.6 mg
$60.00
The membrane-permeable AICAR activates AMP-activated protein kinase (AMPK) via its phosphorylated metabolite AICAR-5'-MP (Cat. No. A 105). Detailed technical information available. References: Fediuc et al., Endocrinology, 147, 5170 - 5177 (2006); Prasad et al., J. Neurosci. Res., 84, 614 - 625 (2006).
Cat. No. A 103
CAS number [2627-69-2]
Purity > 98% HPLC
Storage temperature -20°C / -4°F
Molecular formula C₉H₁₄N₄O₅
Molecular weight [g/mol] 258,2
Absorption max [nm] 265
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 12500
  • 1. Faour W. H., Gomi K.Kennedy C. R. J., Cell. Signal., 20, 2156 - 2164 (2008), "PGE2 Induces COX-2 Expression in Podocytes via the EP4 Receptor through a PKA-independent Mechanism"
  • 2. Narkar V. A., Downes M., Yu R. T., Embler E., Wang Y.-X., Banayo E., Mihaylova M. M., Nelson M. C., Zou Y., Juguilon H., Kang H., Shaw R. J.Evans R. M., Cell, 134, 405 - 415 (2008), "AMPK and PPARdelta Agonists Are Exercise Mimetics"
  • 3. Fediuc S., Gaidhu M. P.Ceddia R. B., Endocrinology, 147, 5170 - 5177 (2006), "Inhibition of Insulin-Stimulated Glycogen Synthesis by 5-Aminoimidasole-4-Carboxamide-1-Beta-D-Ribofuranoside-Induced Adenosine 5'-Monophosphate-Activated Protein Kinase Activation: Interactions with Akt, Glycogen Synthase Kinase 3-3Alpha/Beta, and Glycogen Synthase in Isolated Rat Soleus Muscle"
  • 4. Prasad R., Giri S., Nath N., Singh I.Singh A. K., J. Neurosci. Res., 84, 614 - 625 (2006), "5-Aminoimidazole-4-Carboxamide-1-Beta-4-Ribofuranoside Attenuates Experimental Autoimmune Encephalomyelitis via Modulation of Endothelial-Monocyte Interaction"