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ADP-β-S

Adenosine- 5'- O- (2- thiodiphosphate) ( ADP-β-S ), sodium salt
Cat. No.: A 121
    
CAS No.: [35094-45-2]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: A 121-05
Unit: 5 µmol / ~2.2 mg
$110.00

Modulator of ADP binding proteins with increased metabolic stability. Useful for characterization of ADP-responsive receptors and determination of their stereospecificity and for labelling with thio-reactive reporter groups. Other  β-S-diphosphates are also offered (Cat. Nos. C 079, G 023 and U 011). Detailed technical information available. References: Palea et al., J. Pharmacol. Exp. Ther., 269, 193 - 197 (1994); Bolego et al., Res. Commun. Mol. Pathol. Pharmacol., 87, 75 - 77 (1995); Saiag et al., Brit. J. Pharmacol., 118, 804 - 810 (1996).

 

Vial containing 500 µl of 10 mM aqueous solution of pH 8.5

Cat. No. A 121
CAS number [35094-45-2]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution of pH 8.5
Storage temperature -70°C / -94°F
Molecular formula C₁₀H₁₅N₅O₉P₂S (free acid)
Molecular weight [g/mol] 443,3 (free acid)
Absorption max [nm] 259
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 15200
  • 1. Malmsjö M., Hou M., Pendergast W., Erlinge D.Edvinsson L., Eur. J. Pharmacol., 458, 305 - 311 (2003), "The Stable Pyrimidines UDPbetaS and UTPgammaS Discriminate Between Contractile Cerebrovascular P2 Receptors"
  • 2. Van der Weyden L., Adams D. J., Luttrell B. M., Conigrave A. D.Morris M. B., Mol. Cell. Biochem., 213, 75 - 81 (2000), "Pharmacological Characterization of the P2Y(11) Receptor in Stably Transfected Haematological Cell Lines"
  • 3. Malmsjö M., Hou M., Harden T. K., Ortonne J. P., Pantev E., Edvinsson L.Erlinge D., J. Pharmacol. Exp. Ther., 293, 755 - 760 (2000), "Characterization of Contractile P2 Receptors in Human Coronary Arteries by Use of the Stable Pyrimidines Uridine 5'-O-Thiodiphosphate and Uridine 5'-O-3-Thiotriphosphate"
  • 4. Gillespie P. G., Gillespie S. K. H., Mercer J. A., Shah K.Shokat K. M., J. Biol. Chem., 274, 31373 - 31381 (1999), "Engineering of the Myosin-Iß Nucleotide-binding Pocket to Create Selective Sensitivity to N6-modified ADP Analogs"
  • 5. Laubinger W.Reiser G., Biochem. Pharmacol., 55, 687 - 695 (1998), "Differential Characterization of Binding Sites for Adenine and Uridine Nucleotides in Membranes from Rat Lung as Possible Tools for Studying P2 Receptors in Lung"
  • 6. Zhao Z., Biochem. Biophys. Res. Commun., 218, 480 - 484 (1996), "Thiophosphate Derivatives as Inhibitors of Tyrosine Phosphatases"
  • 7. Saiag B., Hillaire-Buys D., Chapal J., Petit P., Pape D., Rault B., Allain H.Loubatieres-Mariani M. M., Br. J. Pharmacol., 118, 804 - 810 (1996), "Study of the Mechanisms Involved in Adenosine-5'-O-(2-Thiodiphosphate) Induced Relaxation of Rat Thoracic Aorta and Pancreatic Vascular Bed"
  • 8. Palea S., Corsi M., Pietra C., Artibani W., Calpista A., Gaviraghi G.Trist D. G., J. Pharmacol. Exp. Ther., 269, 193 - 197 (1994), "ADP Beta S Induces Contraction of the Human Isolated Urinary Bladder Through a Purinoceptor Subtype Different from P2X and P2Y"
  • 9. Jaffe E. K.Cohn M., Biochemistry, 17, 652 - 657 (1978), "31P Nuclear Magnetic Resonance Spectra of the Thiophosphate Analogues of Adenine Nucleotides; Effects of pH and Mg 2+ Binding"