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Alternative structural projections:

8-pCPT-PET-cGMP

8- (4- Chlorophenylthio)- β- phenyl- 1, N²- ethenoguanosine- 3', 5'- cyclic monophosphate ( 8-pCPT-PET-cGMP ), sodium salt
Membrane-permeant PKG agonist
Cat. No.: C 045
    
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: C 045-05
Unit: 5 µmol / ~3 mg
$149.00
For other salt forms please inquire. Highly membrane-permeant activator of cyclic GMP-dependent protein kinase, but most probably inhibitor of the retinal type cGMP-gated ion channel, thus suitable for distinction between kinase and ion channel mediated effects. Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases. More lipophilic and membrane-permeant compared to 8-Br-PET-cGMP (Cat. No. P 003). Detailed technical information available.
Cat. No. C 045
CAS number [pending]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₄H₁₈ClN₅O₇PS · Na
Molecular weight [g/mol] 609,9
Modifications 1-cGMP, 2-cGMP, 8-cGMP
Target PKG (cGK) Activator
Lipophilicity 3.52
Absorption max [nm] 276
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 40000
  • 1. Paquet-Durand F., Hauck S., Van Veen T., Ueffing M.Ekström P., J. Neurochem., 108, 796 - 810 (2009), "PKG Activity Causes Photoreceptor Cell Death in Two Retinitis pigmentosa Models"