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8-pCPT-2'-O-Me-Ado

8- (4- Chlorophenylthio)- 2'- O- methyladenosine ( 8-pCPT-2'-O-Me-Ado )
Metabolite of the Epac agonist 8-pCPT-2'-O-Me-cAMP
Cat. No.: C 070
    
CAS No.: [1187179-96-9]
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Product Name Price (net) Qty
Cat. No.: C 070-10
Unit: 10 µmol / ~4.2 mg
$248.00
Potential metabolite of the specific Epac activator 8-pCPT-2’-O-Me-cAMP (Cat. No C 041). The corresponding 5’-monophosphate 8-pCPT-2’-O-Me-5’-AMP (Cat. No. C 078)  as well as the nucleobase (Cat. No. C 069) are available as well. Detailed technical information available. Reference: Laxman et al., Proc. Natl. Acad. Sci. USA, 19194 - 19199 (2006).
Cat. No. C 070
CAS number [1187179-96-9]
Purity > 98% HPLC
Storage temperature -20°C / -4°F
Molecular formula C₁₇H₁₈ClN₅O₄S
Molecular weight [g/mol] 423,9
Absorption max [nm] 282
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 16000
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  • 2. Enyeart J. A.Enyeart J. J., PloS One, 4, 0 - 0 (2009), "Metabolites of an Epac-Selective cAMP Analog Induce Cortisol Synthesis by Adrenocortical Cells through a cAMP-Independent Pathway"
  • 3. Waidmann O., Pleli T., Dvorak K., Baehr C., Mondorf U., Plotz G., Biondi R. M., Zeuzem S.Piiper A., J.Biol.Chem., 284, 32256 - 32263 (2009), "Inhibition of the Equilibrative Nucleoside Transporter 1 and Activation of A2A Adenosine Receptors by 8-(4-Chlorophenylthio)-modified cAMP Analogs and their Hydrolytic Products"
  • 4. Holz G. G., Chepurny O. G.Schwede F., Cell. Signal., 20, 10 - 20 (2008), "Epac-selective cAMP Analogs: New Tools with which to Evaluate the Signal Transduction Properties of cAMP-regulated Guanine Nucleotide Exchange Factors"
  • 5. Laxman S., Riechers A., Sadilek M., Schwede F.Beavo J. A., PNAS, 103, 19194 - 19199 (2006), "Hydrolysis Products of cAMP Analogs Cause Transformation of Trypanosoma Brucei from Slender to Stumpy-like Forms"