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8-pCPT-2'-O-Me-5'-AMP

8- (4- Chlorophenylthio)- 2'- O- methyladenosine- 5'- O- monophosphate ( 8-pCPT-2'-O-Me-5'-AMP ), sodium salt
Metabolite of the Epac agonist 8-pCPT-2'-O-Me-cAMP
Cat. No.: C 078
    
CAS No.: [1187179-94-7]
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Product Name Price (net) Qty
Cat. No.: C 078-05
Unit: 5 µmol / ~2.5 mg
$172.00
Potential metabolite of the specific Epac activator 8-pCPT-2’-O-Me-cAMP (Cat. No C 041). The corresponding nucleoside 8-pCPT-2’-O-Me-adenosine (Cat. No. C 070) and the nucleobase 8-pCPT-Ade (Cat. No. C 069) are available as well. Detailed technical information available. Reference: Laxman et al., Proc. Natl. Acad. Sci. USA, 103, 19194 - 19199 (2006).
Cat. No. C 078
CAS number [1187179-94-7]
Purity > 97% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₇H₁₉ClN₅O₇PS (free acid)
Molecular weight [g/mol] 503,9 (free acid)
Absorption max [nm] 282
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 16000
  • 1. Liu H., Enyeart J. J.Enyeart J. A., J. Biol. Chem., 285, 20040 - 20050 (2010), "ACTH Induces CAv3.2. Current and mRNA by cAMP-dependent and cAMP-independent Mechanism"
  • 2. Enyeart J. A.Enyeart J. J., PloS One, 4, 0 - 0 (2009), "Metabolites of an Epac-Selective cAMP Analog Induce Cortisol Synthesis by Adrenocortical Cells through a cAMP-Independent Pathway"
  • 3. Holz G. G., Chepurny O. G.Schwede F., Cell. Signal., 20, 10 - 20 (2008), "Epac-selective cAMP Analogs: New Tools with which to Evaluate the Signal Transduction Properties of cAMP-regulated Guanine Nucleotide Exchange Factors"
  • 4. Laxman S., Riechers A., Sadilek M., Schwede F.Beavo J. A., PNAS, 103, 19194 - 19199 (2006), "Hydrolysis Products of cAMP Analogs Cause Transformation of Trypanosoma Brucei from Slender to Stumpy-like Forms"