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8-OH-Gua

8- Hydroxyguanine ( 8-OH-Gua )
Cat. No.: H 002
    
CAS No.: [5614-64-2]
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Product Name Price (net) Qty
Cat. No.: H 002-100
Unit: 100 µmol / ~17 mg
$114.00

Reference for analysis of oxidative stress RNA/DNA hydrolysates. The corresponding nucleoside is also available (Cat. No. H 001). For other 8-OH nucleosides and nucleotides please inquire. Detailed technical information available. Reference: Kaur & Halliwell, Biochem. J., 318, 21 - 23 (1996).
This compound is also part of the Ko-Libri compound library (K 001)

Cat. No. H 002
CAS number [5614-64-2]
Purity > 95% HPLC
Storage temperature -20°C / -4°F
Molecular formula C₅H₅N₅O₂
Molecular weight [g/mol] 167.1
Absorption max [nm] 245 / 293
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 12300 / 10300
  • 1. Hu C.-W., Chao M.-R.Sie C.-H., Free Radical Biology & Medicine, 48, 89 - 97 (2010), "Urinary Analysis of 8-oxo-7,8-dihydroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanosine by Isotope-dilution LC-MS/MS with Automated Solid-phase Extraction: Study of 8-oxo-7,8-dihydroguanine Stability"
  • 2. Tretyakova N. Y., Niles J. C., Burney S., Wishnok J. S.Tannenbaum S. R., Chem. Res. Toxicol., 12, 459 - 466 (1999), "Peroxynitrite-Induced Reactions of Synthetic Oligonucleotides Containing 8-Oxoguanine"
  • 3. Halliwell B., Mutat. Res., 443, 37 - 52 (1999), "Oxygen and Nitrogen are Pro-carcinogens. Damage to DNA by Reactive Oxygen, Chlorine and Nitrogen Species: Measurement, Mechanism and the Effects of Nutrition"
  • 4. Kaur H.Argentieri D. C., Biochem. J., 318, 21 - 23 (1996), "Measurement of Oxidized and Methylated DNA Bases by HPLC with Electrochemical-detection"
  • 5. Reitz A. B., Goodman M. G., Pope B. L., Argentieri D. C., Bell S. C., Burr L. E., Chourmouzis E., Goodman J. H., Klaubert D. H., Maranoff M. E., Rampulla M. S., Schott M. R.Chen R., J.Med.Chem., 37, 3561 - 3578 (1994), "Small-Molecule Immunostimulants. Synthesis and Activity of 7,8-Disubstitutet Guanosines and Structurally Related Compounds"