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8-OH-dGuo

2'- Deoxy- 8- hydroxyguanosine ( 8-OH-dGuo )
Cat. No.: D 022
    
CAS No.: [88847-89-6]
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Product Name Price (net) Qty
Cat. No.: D 022-05
Unit: 5 µmol / ~1.5 mg
$55.00
Reference for analysis of oxidative stress DNA hydrolysates. The corresponding ribo nucleoside (Cat. No. H 001) and nucleobase (Cat. No. H 002) are available as well. Detailed technical information available. References: Pilger & Ruediger, Int. Arch. Occup. Environ. Health, 80, 1 - 15 (2006); Orimo et al., Cancer Science, 97, 99 - 105 (2006).
Cat. No. D 022
CAS number [88847-89-6]
Purity > 97% HPLC
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₃N₅O₅
Molecular weight [g/mol] 283,3
Absorption max [nm] 245/293
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 12300 / 10300
  • 1. Hu C.-W., Chao M.-R.Sie C.-H., Free Radical Biology & Medicine, 48, 89 - 97 (2010), "Urinary Analysis of 8-oxo-7,8-dihydroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanosine by Isotope-dilution LC-MS/MS with Automated Solid-phase Extraction: Study of 8-oxo-7,8-dihydroguanine Stability"
  • 2. Pilger A.Rüdiger H. W., Int. Arch. Occup. Environ. Health, 80, 1 - 15 (2006), "8-Hydroxy-2'-Deoxyguanosine as a Marker of Oxidative DNA Damage Related to Occupational and Environmental Exposures"
  • 3. Orimo H., Tokura Y., Hino R.Kasai H., Cancer Sci., 97, 99 - 105 (2006), "Formation of 8-Hydroxy-2'-Deoxyguanosine in the DNA of Cultured Human Keratinocytes by Clinically Used Doses of Narrowband and Broadband Ultraviolet B and Psoralen Plus Ultraviolet A"
  • 4. Conners R., Hooley E., Clarke A. R., Thomas S.Brady R. L., J. Mol. Biol., 357, 263 - 274 (2006), "Recognition of Oxidatively Modified Bases within the Biotin-binding Site of Avidin"
  • 5. Masuda M., Suzuki T., Friesen M. D., Ravanat J.-L., Cadet J., Pignatelli B., Nishino H.Oshima H., J. Biol. Chem., 276, 40486 - 40496 (2001), "Chlorination of Guanosine and Other Nucleosides by Hypochlorous Acid and Myeloperoxidase of Activated Human Neutrophils"
  • 6. Cho B. P., Kadlubar F. F., Culp S. J.Evans F. E., Chem. Res. Toxicol., 3, 445 - 452 (1990), "15N Nuclear Magnetic Resonance Studies on the Tauterism of 8-Hydroxy-2'-deoxyguanosine, 8-Hydroxyguanosine, and Other C8-substituted Guanine Nucleosides"