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8-OH-dAdo

2'- Deoxy- 8- hydroxyadenosine ( 8-OH-dAdo )
Cat. No.: D 050
    
CAS No.: [62471-63-0]
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Product Name Price (net) Qty
Cat. No.: D 050-05
Unit: 5 µmol / ~1.3 mg
$55.00
Reference for analysis of oxidative stress DNA hydrolysates. The corresponding ribo nucleoside (Cat. No. H 011) and nucleobase (Cat. No. H 007) are available as well. Detailed technical information available. References: Sodum & Fiala, Chem. Res. Toxicol., 14, 438 - 450 (2001); Frelon et al., Free Radical Res., 36, 499 – 508 (2002).
This compound is also part of the Ko-Libri compound library (K 001)
Cat. No. D 050
CAS number [62471-63-0]
Purity > 97% HPLC
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₃N₅O₄
Molecular weight [g/mol] 267,3
Absorption max [nm] 268
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 11000
  • 1. Conners R., Hooley E., Clarke A. R., Thomas S.Brady R. L., J. Mol. Biol., 357, 263 - 274 (2006), "Recognition of Oxidatively Modified Bases within the Biotin-binding Site of Avidin"
  • 2. Frelon S., Douki T.Cadet J., Free Radical Res., 36, 499 - 508 (2002), "Radical Oxidation of the Adenine Moiety of Nucleoside and DNA: 2-Hydroxy-2'-Deoxyadenosine is a Minor Decomposition Product"
  • 3. Sodum R. S.Fiala E. S., Chem. Res. Toxicol., 14, 438 - 450 (2001), "Analysis of Peroxynitrite Reactions with Guanine, Xanthine, and Adenine Nucleosides by High-Pressure Liquid Chromatography with Electrochemical Detection: C8-Nitration and -Oxidation"