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Alternative structural projections:

8-NBD-cGMP

8- (2- [7- Nitro- 4- benzofurazanyl]aminoethylthio)guanosine- 3', 5'- cyclic monophosphate ( 8-NBD-cGMP ), sodium salt
Fluorescent analogue of cyclic GMP
Cat. No.: N 001
    
CAS No.: [115993-88-9]
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Product Name Price (net) Qty
Cat. No.: N 001-01
Unit: 1 µmol / ~0.6 mg
$165.00
For other salt forms or metabolites please inquire. Potent membrane-permeant fluorescent activator of both isozymes I α and I β of cGMP-dependent protein kinase. While 8-NBD-cGMP is almost nonfluorescent in aqueous solutions, it fluoresces strongly in hydrophobic environments such as hydrophobic protein binding sites (λexc 475 nm, λem 525 nm). Detailed technical information available. Reference: Salowe et al., Biochemistry, 41, 4385 - 4391 (2002).
Cat. No. N 001
CAS number [115993-88-9]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Light-sensitive True
Molecular formula C₁₈H₁₇N₉O₁₀PS · Na
Molecular weight [g/mol] 605,4
Modifications 8-cGMP
Target PKG (cGK) Activator
Excitation max [nm] 475
Emission max [nm] 525
Lipophilicity 2.02
Absorption max [nm] 463
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 22000
Solvent for UV data MeOH
  • 1. Salowe S. P., Wiltsie J., Liberator P. A.Donald R. G. K., Biochemistry, 41, 4385 - 4391 (2002), "The Role of a Parasite-Specific Allosteric Site in the Distinctive Activation Behavior of Eimeria tenella cGMP-Dependent Protein Kinase"
  • 2. Ruf H. H., Rack M., Landgraf W.Hofmann F., in L.M.G. Heilmeyer: Signal Transduction and Protein Phosphorylation NATO ASI Series A: Life Sciences, 135, 99 - 104 (1987), "Binding of Fluorescent Analogs of Cyclic GMP to cGMP-dependent Protein Kinase"