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Alternative structural projections:

8-N₃-ε-cAMP

8- Azido- 1, N⁶- ethenoadenosine- 3', 5'- cyclic monophosphate ( 8-N₃-ε-cAMP ), sodium salt
Immobilizable cAMP analogue for fluorescent tagging
Cat. No.: A 077
    
CAS No.: [60902-12-7]
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Product Name Price (net) Qty
Cat. No.: A 077-01
Unit: 1 µmol / ~0.4 mg
$248.00
For other salt forms or metabolites please inquire. Nonfluorescent cAMP analogue, that can be used for labelling of cAMP receptors. Upon UV-light-induced immobilization the ethenoadenine moiety starts to fluoresce, providing a label for tracing the receptor protein. Detailed technical information available. References: Keeler & Campbell, Biochem. Biophys. Res. Commun., 72, 575 - 80 (1976); Dreyfuss et al., Proc. Nat. Acad. Sci. USA, 75, 1199 - 1203 (1978).
Cat. No. A 077
CAS number [60902-12-7]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Light-sensitive True
Molecular formula C₁₂H₁₀N₈O₆P · Na
Molecular weight [g/mol] 416,2
Modifications 1-cAMP, 8-cAMP
Target PKA (cAK) Activator
Lipophilicity 1.64
Absorption max [nm] 237, 290, 313
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 10000 at 290 nm
  • 1. Jäger R., Russwurm C., Schwede F., Genieser H.-G., Koesling D.Russwurm M., J. Biol. Chem., 287, 1210 - 1219 (2012), "Activation of PDE10 and PDE11 Phosphodiesterases"
  • 2. Dreyfuss G., Schwartz K., Blout E. R., Barrio J. R., Liu F.-T.Leonard N. J., Proc. Natl. Acad. Sci., 75, 1199 - 1203 (1978), "Fluorescent Photoaffinity Labeling: Adenosine 3', 5'- cyclic Monophosphate Receptor Sites"
  • 3. Keeler E. K.Campbell P., Biochem. Biophys. Res. Comm., 72, 575 - 580 (1976), "A Fluorescent Photo-Affinity Label for Cyclic AMP Binding Proteins"