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8-N₃-6-[DY-547]-AE-cAMP

8- Azido- N⁶- (2- [DY-547]- aminoethyl)adenosine- 3', 5'- cyclic monophosphate ( 8-N₃-6-[DY-547]-AE-cAMP ), sodium salt
Fluorescent cAMP analogue for photoaffinity labeling
Cat. No.: A 100
    
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: A 100-001
Unit: 0.1 µmol / ~0.1 mg
$330.00
For other salt forms please inquire. 8-N3-6-[DY-547]-AE-cAMP is a light sensitive analogue for photoaffinity labelling. It can be immobilized within a cyclic AMP binding site by illumination with UV light. The fluorescent reporter group connected to position 6 of the adenine nucleobase can be excitated at 557 nm and emits with 574 nm. Detailed technical information available. Reference: Park et al., Cell, 148, 421 - 433 (2012).
Cat. No. A 100
CAS number [pending]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Light-sensitive True
Molecular formula C₄₂H₄₈N₁₁O₁₃PS₂ · Na₂
Molecular weight [g/mol] 1056
Modifications 8-cAMP
Target PKA (cAK) Activator
Excitation max [nm] 557
Emission max [nm] 574
Absorption max [nm] 559
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 150000
Solvent for UV data EtOH
  • 1. Park S. J., Ahmad F., Philp A., Baar K., Williams T., Luo H. B., Ke H. M., Rehmann H., Taussig R., Brown A. L., Kim M. K., Beaven M. A., Burgin A. B., Manganiello V.Chung J. H., Cell., 148, 421 - 433 (2012), "Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterase"
  • 2. Miyoshi K., Kawakami N., Horio S.Fukui H., Methods Find. Exp. Clin. Pharmacol., 25, 343 - 347 (2003), "Inhibition of Histamine hi Receptor Downregulation by KT5823, a Protein Kinase G Inhibitor"
  • 3. Bryce P. J., Dascombe M. J.Hutchinson I. V., Immunopharmacology, 41, 139 - 146 (1999), "Immunomodulatory Effects of Pharmacological Elevation of Cyclic AMP in T Lymphocytes Proceed Via a Protein Kinase A Independent Mechanism"