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Alternative structural projections:

8-HA-cAMP

8- Hexylaminoadenosine- 3', 5'- monophosphate, sodium salt ( 8-HA-cAMP )
Site-selective PKA agonist
Cat. No.: H 006
    
CAS No.: [59212-44-1]
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Product Name Price (net) Qty
Cat. No.: H 006-05
Unit: 5 µmol / ~2.3 mg
$98.00
Site-selective analogue of cyclic AMP which prefers site B of PKA I. High membrane permeability and improved stability towards phosphodiesterases. Detailed technical information available. Reference: Schwede et al., Biochemistry, 39, 8803 - 8812 (2000).
Cat. No. H 006
CAS number [59212-44-1]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₆H₂₄N₆O₆P · Na
Molecular weight [g/mol] 450,4
Modifications 8-cAMP
Target PKA (cAK) Activator
Lipophilicity 2.83
Absorption max [nm] 273
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
  • 1. Hahnefeld C.Herberg F. W., Abstract of the 13th Protein Kinase Symposium p. 14, 0, 12 - 15 (2002), "cAMP-dependent Protein Kinase: cAMP Analog Screening Using Surface Plasmon Resonance and Fluorescent Methods"
  • 2. Schwede F., Christensen A., Liauw S., Hippe T., Kopperud R. K., Jastorff B.Doeskeland S. O., Biochemistry, 39, 8803 - 8812 (2000), "8-Substituted cAMP Analogues Reveal Marked Differences in Adaptability, Hydrogen Bonding, and Charge Accomodation between Homologous Binding Sites (AI/AII and BI/BII) in cAMP Kinase I and II"
  • 3. Sasaki Y., Suzuki N., Sowa T., Nozawa R.Yokota T., Biochemistry, 15, 1408 - 1413 (1976), "Effects of 8-Substituted Adenosine 3',5'-monophosphate Derivatives on High Km Phosphodiesterase Activity"