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8-[DY-547]-AET-cGMP

8- (2- [DY-547]- aminoethylthio)guanosine- 3', 5'- cyclic monophosphate ( 8-[DY-547]-AET-cGMP ), sodium salt
cyclic GMP conjugated with the fluorescent dye DY-547
Cat. No.: D 087
    
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: D 087-001
Unit: 0.1 µmol / ~0.1 mg
$240.00
For other salt forms or metabolites please inquire. Fluorescent cGMP analogue (λexc 557 nm, λem 574 nm), e.g. for research focussed on kinetic studies of CNG ion channels and other cGMP-reponsive binding proteins. Detailed technical information available. Reference: Biskup et al., Nature, 446, 440 - 443 (2007).
Cat. No. D 087
CAS number [pending]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Light-sensitive True
Molecular formula C₄₂H₄₉N₈O₁₄PS₃ · Na₂
Molecular weight [g/mol] 1063,0
Modifications 8-cGMP
Target PKG (cGK) Activator
Excitation max [nm] 557
Emission max [nm] 574
Absorption max [nm] 559
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 150000
Solvent for UV data EtOH
  • 1. Nache V., Eick T., Schulz E., Schmauder R.Benndorf K., Nature Commun., 4, 1 - 9 (2013), "Hysteresis of Ligand Binding in CNGA1 Ion Channels"
  • 2. Nache V., Zimmer T., Wongsamitkul N., Schmauder R., Kusch J., Reinhardt L., Bönigk W., Seifert R., Biskup C., Schwede F.Benndorf K., Sci. Signal., 5, 0 - 0 (2012), "Differential Regulation by Cyclic Nucleotides of the CNGA4 and CNGB1b Subunits in Olfactory Cyclic Nucleotide-Gated Channels"
  • 3. Biskup C., Kusch J., Schulz E., Nache V., Schwede F., Lehmann F., Hagen V.Benndorf K., Nature, 446, 440 - 443 (2007), "Relating ligand binding to activation gating in CNGA2 channels"