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8-CPT-cAMP

8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphate ( 8-CPT-cAMP ), sodium salt
Lipophilic activator of both cAMP- and cGMP-dependent protein kinase and of Epac
Cat. No.: C 010
    
CAS No.: [93882-12-3]
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Product Name Price (net) Qty
Cat. No.: C 010-100
Unit: 100 µmol / ~49 mg
$63.00
highly purified, typical fluorescent impurities removed. For other salt forms of 8-CPT-cAMP please inquire. Lipophilic activator of both cAMP- and cGMP-dependent protein kinase and of Epac. Higher activation potential compared to cAMP; excellent cell membrane permeability, improved phosphodiesterase stability and high site selectivity preferring site B of cAK type II. Detailed technical information and selected references available. Reference: Geiger et al.: Proc. Natl. Acad. Sci. USA, 89, 1031 - 1035 (1992). Caution: Despite its name this analogue is not selective, but activates cGMP-dependent protein kinase as well! In addition, it increases the basal cGMP level by inhibition of PDE V (Murray et al., Biochem. Pharmacol., 44, 2303 - 2306 (1992)).
Cat. No. C 010
CAS number [93882-12-3]
Purity > 99% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₆H₁₄ClN₅O₆PS · Na
Molecular weight [g/mol] 493,8
Modifications 8-cAMP
Target PKA (cAK) Activator, PKG (cGK) Activator
Lipophilicity 2.65
Absorption max [nm] 282
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 16000
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