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8-Cl-dGuo

8- Chloro- 2'- deoxyguanosine ( 8-Cl-dGuo )
Cat. No.: C 025
    
CAS No.: [437715-62-3]
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Product Name Price (net) Qty
Cat. No.: C 025-05
Unit: 5 µmol / ~1.5 mg
$120.00
Analogue of potential interest in research on chlorine-stressed DNA. Detailed technical information available. Reference: Masuda et al., J. Biol. Chem., 276, 40486 - 40496 (2001).
Cat. No. C 025
CAS number [437715-62-3]
Purity > 95% HPLC
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₂ClN₅O₄
Molecular weight [g/mol] 301,7
Absorption max [nm] 258
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 15000
  • 1. Stanley N. R., Pattison D. I.Hawkins C. L., Chem. Res. Toxicol., 23, 1293 - 1302 (2010), "Ability of Hypochlorous Acid and N-Chloramines to Chlorinate DNA and Its Constituents"
  • 2. Badouard C., Masuda M., Nishino H., Cadet J., Favier A.Ravanat J.-L., J. Chromatogr., 827, 26 - 31 (2005), "Detection of Chlorinated DNA and RNA Nucleosides by HPLC Coupled to Tandem Mass Spectrometry as Potential Biomarkers of Inflammation"
  • 3. Suzuki T., Masuda M., Friesen M. D., Fenet B.Oshima H., Nucl. Acids Res., 30, 2555 - 2564 (2002), "Novel Products Generated from 2'-Deoxyguanosine by Hypochlorous Acid or a Myeloperoxidase-H2O2-Cl--System: Identification of Diimino-imidazole and Amino-imidazolone Nucleosides"
  • 4. Suzuki T., Masuda M., Friesen M. D., Fenet B.Ohshima H., Nucl. Acids Res., 30, 2555 - 2564 (2002), "Novel Products Generated from 2'-Deoxyguanosine by Hypochlorous Acid or a Myeloperoxidase-H2O2-Cl System: Identification of Diimino-imidazole and Amino-imidazolone nucleosides"
  • 5. Masuda M., Suzuki T., Friesen M. D., Ravanat J.-L., Cadet J., Pignatelli B., Nishino H.Oshima H., J. Biol. Chem., 276, 40486 - 40496 (2001), "Chlorination of Guanosine and Other Nucleosides by Hypochlorous Acid and Myeloperoxidase of Activated Human Neutrophils"