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8-Cl-dAdo

8- Chloro- 2'- deoxyadenosine ( 8-Cl-dAdo )
Cat. No.: C 024
    
CAS No.: [85562-55-6]
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Product Name Price (net) Qty
Cat. No.: C 024-05
Unit: 5 µmol / ~1.4 mg
$120.00
Lipophilic analogue of 2'-deoxyadenosine (Coomber et al., Int. J. Parasitol., 24, 357 - 365 (1994)), and of potential interest in research on chlorine-stressed DNA. Detailed technical information available.
Cat. No. C 024
CAS number [85562-55-6]
Purity > 95% HPLC
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₂ClN₅O₃
Molecular weight [g/mol] 285,7
Absorption max [nm] 262
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
  • 1. Stanley N. R., Pattison D. I.Hawkins C. L., Chem. Res. Toxicol., 23, 1293 - 1302 (2010), "Ability of Hypochlorous Acid and N-Chloramines to Chlorinate DNA and Its Constituents"
  • 2. Badouard C., Masuda M., Nishino H., Cadet J., Favier A.Ravanat J.-L., J. Chromatogr., 827, 26 - 31 (2005), "Detection of Chlorinated DNA and RNA Nucleosides by HPLC Coupled to Tandem Mass Spectrometry as Potential Biomarkers of Inflammation"
  • 3. Masuda M., Suzuki T., Friesen M. D., Ravanat J.-L., Cadet J., Pignatelli B., Nishino H.Oshima H., J. Biol. Chem., 276, 40486 - 40496 (2001), "Chlorination of Guanosine and Other Nucleosides by Hypochlorous Acid and Myeloperoxidase of Activated Human Neutrophils"
  • 4. Coomber D. W. J., O'Sullivan W. J.Gero A. M., Int. J. Parasitol., 24, 357 - 365 (1994), "Adenosine Analogues as Antimetabolites against Plasmodium Falciparum Malaria"