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Lipophilic analogue of 2'-deoxyadenosine (Coomber et al., Int. J. Parasitol., 24, 357 - 365 (1994)), and of potential interest in research on chlorine-stressed DNA. Detailed technical information available.
Cat. No.
C 024
CAS number
[85562-55-6]
Purity
> 95% HPLC
Storage temperature
-20°C / -4°F
Molecular formula
C₁₀H₁₂ClN₅O₃
Molecular weight [g/mol]
285.7
Absorption max [nm]
262
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹]
17000
1. Stanley N. R., Pattison D. I.Hawkins C. L., Chem. Res. Toxicol., 23, 1293 - 1302 (2010), "Ability of Hypochlorous Acid and N-Chloramines to Chlorinate DNA and Its Constituents"
2. Badouard C., Masuda M., Nishino H., Cadet J., Favier A.Ravanat J.-L., J. Chromatogr., 827, 26 - 31 (2005), "Detection of Chlorinated DNA and RNA Nucleosides by HPLC Coupled to Tandem Mass Spectrometry as Potential Biomarkers of Inflammation"
3. Masuda M., Suzuki T., Friesen M. D., Ravanat J.-L., Cadet J., Pignatelli B., Nishino H.Oshima H., J. Biol. Chem., 276, 40486 - 40496 (2001), "Chlorination of Guanosine and Other Nucleosides by Hypochlorous Acid and Myeloperoxidase of Activated Human Neutrophils"
4. Coomber D. W. J., O'Sullivan W. J.Gero A. M., Int. J. Parasitol., 24, 357 - 365 (1994), "Adenosine Analogues as Antimetabolites against Plasmodium Falciparum Malaria"