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8-Cl-cAMP-AM

8- Chloroadenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 8-Cl-cAMP-AM )
Metabolically activatable prodrug form of 8-Cl-cAMP
Cat. No.: C 050
    
CAS No.: [pending]
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Product Name Price (net) Qty
Cat. No.: C 050-01
Unit: 1 µmol / ~0.4 mg
$134.00

Membrane-permeant precursor of the PKA activator 8-Cl-cAMP (Cat. No. C 007). Metabolic activation by esterases releases the polar active analogue, which is trapped inside the cell. Detailed technical information available. Reference: J. Kruppa, Ph.D. thesis, University of Bremen, Germany, 1996. Biolog also offers Phosphate tris(acetoxymethyl)ester (PO4-AM3, Cat. No. P 030) which is recommended as control reagent in nucleotide-AM ester applications.

Cat. No. C 050
CAS number [pending]
Purity > 97% HPLC for mixture of isomers
Storage temperature -20°C / -4°F
Molecular formula C₁₃H₁₅ClN₅O₈P
Molecular weight [g/mol] 435,7
Modifications 8-cAMP
Target PKA (cAK) Activator
Absorption max [nm] 262
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
  • 1. Kruppa J., Ph. D. Thesis Bremen/Germany, 0, 0 - 0 (1996), "Neue Alkylierte cAMP-Derivate: Synthese und Biologische Eigenschaften"