0 Items - $0.00
Categories
A to Z

8-Cl-ATP

8- Chloroadenosine- 5'- triphosphate ( 8-Cl-ATP ), sodium salt
Cat. No.: C 018
    
CAS No.: [185341-71-3]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: C 018-05
Unit: 5 µmol / ~2.7 mg
$187.00

For other salt forms or a guaranteed higher purity please inquire. Corresponding triphosphate for research on 8-chloro cyclic AMP (Cat. No. C 007) and 8-Cl-adenosine (Cat. No. C 006), respectively. Detailed technical information available. References: Tagliaferri et al., Cancer Res., 48, 1642 - 1650 (1988); Gandhi et al., Cancer Res., 61, 5474 - 5479 (2001).

 

Vial containing 500 µl of 10 mM aqueous solution of pH 7.6

Cat. No. C 018
CAS number [185341-71-3]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution of pH 7.6
Storage temperature -70°C / -94°F
Molecular formula C₁₀H₁₅ClN₅O₁₃P₃ (free acid)
Molecular weight [g/mol] 541,6 (free acid)
Absorption max [nm] 262
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
  • 1. Dennison J. B., Ayres M., Kaluarachchi K., Plunkett W.Gandhi V., J. Biol. Chem., 285, 8022 - 8030 (2010), "Intracellular Succinylation of 8-Chloroadenosine and its Effect on Fumarate Levels"
  • 2. Balakrishnan K., Stellrecht C. M., Genini D., Ayres M., Wierda W. G., Keating M. J., Leoni L. M.Gandhi V., Blood, 105, 4455 - 4462 (2005), "Cell Death of Bioenergetically Compromised and Transcriptionally Challenged CLL Lymphocytes by Chlorinated ATP"
  • 3. Chen L. S.Sheppard T. L., J. Biol. Chem., 279, 40405 - 40411 (2004), "Chain Termination and Inhibition of Saccharomyces cerevisiae Poly(A) Polymerase by C-8-modified ATP Analogs"
  • 4. Gandhi V., Chen W., Ayres M., Rhie J. K., Madden T. L.Newman R. A., Cancer Chemother. Pharmacol., 50, 85 - 94 (2002), "Plasma and Cellular Pharmacology of 8-Chloro-Adenosine in Mice and Rats"
  • 5. Gandhi V., Ayres M., Halgren R. G., Krett N. L., Newman R. A.Rosen S. T., Cancer Res., 61, 5474 - 5479 (2001), "8-Chloro-cAMP and 8-Chloro-Adenosine Act by the Same Mechanism in Multiple Myeloma Cells"
  • 6. Cummings J., Langdon S. P., Ritchie A. A., Burns D. J., Mackay J., Stockman P., Leonard R. C. F.Miller W. R., Ann. Oncol., 7, 291 - 296 (1996), "Pharmacokinetics, Metabolism and Tumour Disposition of 8-Chloroadenosine 3',5'-Monophosphate in Breast Cancer Patients and Xenograft Bearing Mice"
  • 7. Van Lookeren Campagne M. M., Diaz F. V., Jastorff B.Kessin R. H., Cancer Res., 51, 1600 - 1605 (1991), "8-Chloroadenosine 3',5'-Monophosphate Inhibits the Growth of Chinese Hamster Ovary and Molt-4 Cells Through its Adenosine Metabolite"
  • 8. Tagliaferri P., Katsaros D., Clair T., Ally S., Tortora G., Neckers L. M., Rubalcava B., Parandoosh Z., Chang Y.-A., Revankar G. R., Crabtree G. W., Robins R. K.Cho-Chung Y. S., Cancer Res., 48, 1642 - 1650 (1988), "Synergistic Inhibition of Growth of Breast and Colon Human Cancer Cell Lines by Site-selective Cyclic AMP Analogs"