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8-Cl-ADP

8- Chloroadenosine- 5'- O- diphosphate ( 8-Cl-ADP ), sodium salt
Cat. No.: C 042
    
CAS No.: [185341-69-9]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: C 042-05
Unit: 5 µmol / ~2.3 mg
$176.00

For other salt forms please inquire. Analogue of adenosine-5’-diphosphate, metabolite of 8-Cl-cAMP (Cat. No. C 007) and 8-Cl-adenosine (Cat. No. C 006), respectively, and reactive precursor for 8-modified ADP derivatives. Detailed technical information available. Reference: Gandhi, et al., Cancer Chemother. Pharmacol., 50, 85 - 94 (2002).

 

Vial containing 500 µl of 10 mM aqueous solution of pH 7.6

Cat. No. C 042
CAS number [185341-69-9]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution of pH 7.6
Storage temperature -70°C / -94°F
Molecular formula C₁₀H₁₄ClN₅O₁₀P₂ (free acid)
Molecular weight [g/mol] 461,7 (free acid)
Absorption max [nm] 262
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
  • 1. Dennison J. B., Ayres M., Kaluarachchi K., Plunkett W.Gandhi V., J. Biol. Chem., 285, 8022 - 8030 (2010), "Intracellular Succinylation of 8-Chloroadenosine and its Effect on Fumarate Levels"
  • 2. Gandhi V., Chen W., Ayres M., Rhie J. K., Madden T. L.Newman R. A., Cancer Chemother. Pharmacol., 50, 85 - 94 (2002), "Plasma and Cellular Pharmacology of 8-Chloro-Adenosine in Mice and Rats"
  • 3. Gandhi V., Ayres M., Halgren R. G., Krett N. L., Newman R. A.Rosen S. T., Cancer Res., 61, 5474 - 5479 (2001), "8-Chloro-cAMP and 8-Chloro-Adenosine Act by the Same Mechanism in Multiple Myeloma Cells"