0 Items - $0.00
A to Z

8-Cl-Ade

8- Chloroadenine ( 8-Cl-Ade )
Cat. No.: C 023
    
CAS No.: [28128-28-1]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: C 023-10
Unit: 10 µmol / ~1.7 mg
$61.00
Biomarker for analysis of chlorine stressed DNA / RNA  and potential metabolite of 8-chloroadenosine (Cat. No. C 006) and 8-Cl-cAMP (Cat. No. C 007). Detailed technical information available. References: Han et al., J. Pharmacol. Exper. Ther., 265, 790 - 794 (1992); Whiteman at al., Biomarkers 4, 303 - 310 (1999).
This compound is also part of the Ko-Libri compound library.
Cat. No. C 023
CAS number [28128-28-1]
Purity > 95% HPLC
Storage temperature -20°C / -4°F
Molecular formula C₅H₄ClN₅
Molecular weight [g/mol] 169,6
Absorption max [nm] 268
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
  • 1. Gandhi V., Chen W., Ayres M., Rhie J. K., Madden T. L.Newman R. A., Cancer Chemother. Pharmacol., 50, 85 - 94 (2002), "Plasma and Cellular Pharmacology of 8-Chloro-Adenosine in Mice and Rats"
  • 2. Whiteman M., Jenner A.Halliwell B., Biomarkers, 4, 303 - 310 (1999), "8-Chloroadenine: A Novel Product Formed from Hypochlorous Acid-induced Damage to Calf Thymus DNA"
  • 3. Kozlowska M., Smolenski R. T., Makarewicz W., Hoffmann C., Jastorff B.Swierczynski J., Toxicol. Lett., 104, 171 - 181 (1999), "ATP Depletion, Purine Riboside Triphosphate Accumulation and Rat Thymocyte Death Induced by Purine Riboside"
  • 4. Vintermyr O. K., Böe R., Brustugun O. T., Maronde E., Aakvaag A.Doeskeland S. O., Endocrinology, 136, 2513 - 2520 (1995), "Cyclic Adenosine Monophosphate (cAMP) Analogs 8-Cl- and 8-NH(2)-cAMP Induce Cell Death Independently of cAMP Kinase-Mediated Inhibition of the G(1)/S Transition in Mammary Carcinoma Cells (MCF-7)"
  • 5. Han Z., Chatterjee D.Wyche J. H., J. Pharmacol. Exp. Ther., 265, 790 - 794 (1992), "Proliferation of Nontransformed Cells is Inhibited by Adenosine Metabolite of But Not by Parental 8-Cl-Cyclic AMP"
  • 6. Jastorff B.Freist W., Bioorg. Chem., 3, 103 - 113 (1974), "Synthesis and Biological Activities of cyclic AMP Analogs Modified in the 1, 2 and 2'- Positions"