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8-Cl-5'-AMP

8- Chloroadenosine- 5'- O- monophosphate ( 8-Cl-5'-AMP ), sodium salt
Potential metabolite of 8-Cl-cAMP
Cat. No.: C 016
    
CAS No.: [37676-40-7]
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Product Name Price (net) Qty
Cat. No.: C 016-05
Unit: 5 µmol / ~1.9 mg
$121.00
Potential metabolite of 8-chloroadenosine-3',5'-cyclic monophosphate (8-Cl-cAMP, Cat. No. C 007). For other metabolites not listed in this catalogue, please inquire. Detailed technical information available. References: Han et al., J. Pharmacol. Exper. Ther., 265, 790 - 794 (1992); Halgren et al., Blood, 92, 2893 - 2898 (1998).
Cat. No. C 016
CAS number [37676-40-7]
Purity > 97% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₃ClN₅O₇P (free acid)
Molecular weight [g/mol] 381,7 (free acid)
Absorption max [nm] 262
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
  • 1. Dennison J. B., Ayres M., Kaluarachchi K., Plunkett W.Gandhi V., J. Biol. Chem., 285, 8022 - 8030 (2010), "Intracellular Succinylation of 8-Chloroadenosine and its Effect on Fumarate Levels"
  • 2. Gandhi V., Chen W., Ayres M., Rhie J. K., Madden T. L.Newman R. A., Cancer Chemother. Pharmacol., 50, 85 - 94 (2002), "Plasma and Cellular Pharmacology of 8-Chloro-Adenosine in Mice and Rats"
  • 3. Gandhi V., Ayres M., Halgren R. G., Krett N. L., Newman R. A.Rosen S. T., Cancer Res., 61, 5474 - 5479 (2001), "8-Chloro-cAMP and 8-Chloro-Adenosine Act by the Same Mechanism in Multiple Myeloma Cells"
  • 4. Kozlowska M., Smolenski R. T., Makarewicz W., Hoffmann C., Jastorff B.Swierczynski J., Toxicol. Lett., 104, 171 - 181 (1999), "ATP Depletion, Purine Riboside Triphosphate Accumulation and Rat Thymocyte Death Induced by Purine Riboside"
  • 5. Halgren R. G., Traynor A. E., Pillay S., Zell J. L., Heller K. F., Krett N. L.Rosen S. T., Blood, 92, 2893 - 2898 (1998), "8-Cl-cAMP Cytotoxicity in both Steroid Sensitive and Insensitive Multiple Myeloma Cell Lines is Mediated by 8-Cl-Adenosine"
  • 6. Han Z. Y., Chatterjee D., Early J., Pantazis P., Hendrickson E. A.Wyche J. H., Cancer Res., 56, 1621 - 1628 (1996), "Isolation and Characterization of an Apoptosis-Resistant Variant of Human Leukemia HL-60 Cells that has Switched Expression from Bcl-2 to Bcl-X(L)"
  • 7. Vintermyr O. K., Böe R., Brustugun O. T., Maronde E., Aakvaag A.Doeskeland S. O., Endocrinology, 136, 2513 - 2520 (1995), "Cyclic Adenosine Monophosphate (cAMP) Analogs 8-Cl- and 8-NH(2)-cAMP Induce Cell Death Independently of cAMP Kinase-Mediated Inhibition of the G(1)/S Transition in Mammary Carcinoma Cells (MCF-7)"
  • 8. Han Z., Chatterjee D.Wyche J. H., J. Pharmacol. Exp. Ther., 265, 790 - 794 (1992), "Proliferation of Nontransformed Cells is Inhibited by Adenosine Metabolite of But Not by Parental 8-Cl-Cyclic AMP"