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8-Br-NAD⁺

β- Nicotinamide- 8- bromoadenine dinucleotide ( 8-Br-NAD⁺ ), sodium salt
Cat. No.: N 017
    
CAS No.: [2022926-16-3]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: N 017-10
Unit: 10 µmol / ~7.4 mg
$108.00
For other salt forms or higher purity please inquire. Analogue of β-NAD+ that can be utilized as a substrate by the ADP-ribosyl cyclase CD38 to produce the cADPR antagonist 8-Br-cADPR (Cat. No. B 065) and for receptor mapping studies. Detailed technical information available. Reference: Partida-Sanchez et al., Nature Med., 7, 1209 - 1216 (2001).
Cat. No. N 017
CAS number [2022926-16-3]
Purity > 95% HPLC
Salt form Sodium
Storage temperature -70°C / -94°F
Molecular formula C₂₁H₂₆BrN₇O₁₄P₂ (free acid)
Molecular weight [g/mol] 742,3 (free acid)
Absorption max [nm] 264
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 21200
  • 1. Mayo L., Jacob-Hirsch J., Amariglio N., Rechavi G., Moutin M.-J., Lund F. E.Stein R., J. Immunol., 181, 92 - 103 (2008), "Dual Role of CD38 in Microglial Activation and Activation-Induced Cell-Death"
  • 2. Partida-Sánchez S., Iribarren P., Moreno-García M. E., Gao J.-L., Murphy P. M., Oppenheimer N., Wang J. M.Lund F. E., J. Immunol., 172, 1896 - 1906 (2004), "Chemotaxis and Calcium Responses of Phagocytes to Formyl Peptide Receptor Ligands Is Differentially Regulated by Cyclic ADP Ribose"
  • 3. Partida-Sanchez S., Cockayne D. A., Monard S., Jacobson E. L., Oppenheimer N., Garvy B., Kusser K., Goodrich S., Howard M., Harmsen A., Randall T. D.Lund F. E., Nat. Med., 7, 1209 - 1216 (2001), "Cyclic ADP-Ribose Production by CD38 Regulates Intracellular Calcium Release, Extracellular Calcium Influx and Chemotaxis in Neutrophils and is Required for Bacterial Clearance In Vivo"