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8-Br-dGuo

8- Bromo- 2'- deoxyguanosine ( 8-Br-dGuo )
Cat. No.: B 021
    
CAS No.: [13389-03-2]
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Product Name Price (net) Qty
Cat. No.: B 021-10
Unit: 10 µmol / ~3.5 mg
$120.00
Useful as starting structure for 2'-deoxyguanosine nucleotides modified in position 8, and of potential interest in research on bromine-stressed DNA. Detailed technical information available. References: Lin, J. Med. Chem., 28, 1194 - 1198 (1985); Shen et al., Biochemistry, 40, 2041 - 2051 (2001); Esposito et al., Org. Biomol. Chem., 2, 313 - 318 (2004). 
This compound is also part of the Ko-Libri compound library (K 001)
Cat. No. B 021
CAS number [13389-03-2]
Purity > 98% HPLC
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₂BrN₅O₄
Molecular weight [g/mol] 346,2
Absorption max [nm] 258
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 15000
  • 1. Esposito V., Randazzo A., Piccialli G., Petraccone L., Giancola C.Mayol L., Org. Biomol. Chem., 2, 313 - 318 (2004), "Effects of an 8-Bromodeoxyguanosine Incorporation on The Parallel Quadruplex Structure [d(TGGGT)]4"
  • 2. Shen Z., Mitra S. N., Wu W., Chen Y., Yang Y., Qin J.Hazen S. L., Biochemistry, 40, 2041 - 2051 (2001), "Eosinophil Peroxidase Catalyzes Bromination of Free Nucleosides and Double-Stranded DNA"
  • 3. Lin T.-S., Cheng J.-C., Ishiguro K.Sartorelli A. C., J. Med. Chem., 28, 1194 - 1198 (1985), "8-Substituted Guanosine and 2´-Deoxyguanosine Derivates as Potential Inducers of the Differentiation of Friend Erythroleukemia"