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8-APT-cGMP

8- (2- Aminophenylthio)guanosine- 3', 5'- monophosphate ( 8-APT-cGMP ), sodium salt
Isozyme-selective activator of PKG I α
Cat. No.: A 032
    
CAS No.: [144509-87-5]
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Product Name Price (net) Qty
Cat. No.: A 032-05
Unit: 5 µmol / ~2.4 mg
$132.00
For other salt forms or metabolites of 8-APT-cGMP please inquire. Isozyme-selective activator of cGMP-dependent protein kinase I a which prefers type I a over I ß by a factor of 200. Detailed technical information with references available. References: Haynes, Br. J. Pharmacol., 130, 685 - 691 (2000); Cook & Haynes, Cell. Signal., 16, 253 - 261 (2004).
Cat. No. A 032
CAS number [144509-87-5]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₆H₁₆N₆O₇PS · Na
Molecular weight [g/mol] 490,4
Modifications 8-cGMP
Target PKG (cGK) Activator
Lipophilicity 2.38
Absorption max [nm] 278
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 18000
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  • 2. Lohmann S. M.Walter U., Frontiers Biosci., 10, 1313 - 1328 (2005), "Tracking Functions of cGMP-dependent Protein Kinase"
  • 3. Cook A. L. M.Haynes J. M., Cell. Signal., 16, 253 - 261 (2004), "Protein Kinase GII-mediated Proliferative Effects in Human Cultured Prostatic Stromal Cells"
  • 4. Deng W., Parbhu-Patel A., Meyer D. J.Baker D. A., Biochem. J., 374, 559 - 565 (2003), "The Role of Two Novel Regulatory Sites in the Activation of the cGMP-dependent Protein Kinase from Plasmodium Falciparum"
  • 5. Gerzanich V., Ivanov A., Ivanova S., Yang J. B., Zhou H., Dong Y. F.Simard J. M., Circ. Res., 93, 805 - 812 (2003), "Alternative Splicing of cGMP-dependent Protein Kinase 1 in Angiotensin-hypertension - Novel Mechanism for Nitrate Tolerance in Vascular Smooth Muscle"
  • 6. Salowe S. P., Wiltsie J., Liberator P. A.Donald R. G. K., Biochemistry, 41, 4385 - 4391 (2002), "The Role of a Parasite-Specific Allosteric Site in the Distinctive Activation Behavior of Eimeria tenella cGMP-Dependent Protein Kinase"
  • 7. Deng W.Baker D. A., Mol. Microbiol., 44, 1141 - 1151 (2002), "A Novel Cyclic GMP-dependent Protein Kinase is Expressed in the Ring Stage of the Plasmodium Falciparum Life Cycle"
  • 8. Teede H., van der Zypp A.Majewski H., Clin. Sci., 100, 473 - 479 (2001), "Gender Differences in Protein Kinase G-mediated Vasorelaxation of Rat Aorta"
  • 9. Haynes J. M., Br. J. Pharmacol., 130, 685 - 691 (2000), "A(2A) Adenosine Receptor Mediated Potassium Channel Activation in Rat Epididymal Smooth Muscle"
  • 10. Francis S. H.Corbin J. D., Crit. Rev. Clin. Lab. Sci., 36, 275 - 328 (1999), "Cyclic Nucleotide-Dependent Protein Kinases: Intracellular Receptors for cAMP and cGMP Action"
  • 11. Pfeifer A., Ruth P., Dostmann W., Sausbier M., Klatt P.Hofmann F., in Rev. Physiol. Biochem. Pharmacol. Berlin / Springer, 135, 105 - 149 (1999), "Structure and Function of cGMP-Dependent Protein Kinases"
  • 12. Francis S. H.Corbin J. D., Adv. Pharmacol., 26, 115 - 170 (1994), "Progress in Understanding the Mechanism and Function of Cyclic GMP-Dependent Protein Kinase"