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Alternative structural projections:

8-AHA-2-Cl-cAMP

8- (6- Aminohexylamino)- 2- chloroadenosine- 3', 5'- cyclic monophosphate ( 8-AHA-2-Cl-cAMP )
Cat. No.: A 199
    
CAS No.: [pending]
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Product Name Price (net) Qty
Cat. No.: A 199-05
Unit: 5 µmol / ~2.4 mg
$225.00
For other salt forms please inquire.
Cyclic AMP analogue with high selectivity for side B I of PKA. Combined with A l-selective analogues (e.g. 6-Bnz-8-PIP-cAMP, Cat. No. B 055) synergistic activation of PKA typ I ist achieved. Detailed technical information available. Reference: Huseby et al., Cell Death Dis., 2, e237 (2011)
Cat. No. A 199
CAS number [pending]
Purity > 98% HPLC
Salt form Free acid
Storage temperature -20°C / -4°F
Molecular formula C₁₆H₂₅ClN₇O₆P
Molecular weight [g/mol] 477,8
Modifications 2-cAMP, 8-cAMP
Target PKA (cAK) Activator
Lipophilicity 1.62
Absorption max [nm] 281
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
  • 1. Gausdal G., Wergeland A., Skavland J., Nguyen E., Pendino F., Rouhee N., McCormack E., Herfindal L., Kleppe R., Havemann U., Schwede F., Bruseud O., Gjertsen B. T., Lanotte M., Segal-Bendirdjian E.Doskeland S. O., Cell Death Dis., 4, 0 - 0 (2013), "Cyclic AMP Can Promote APL Progression and Protect Myeloid Leukemia Cells Against Anthracycline-Induced Apoptosis"
  • 2. Huseby S., Gausdal G., Keen T. J., Kjærland E., Krakstad C., Myhren L., Brønstad K., Kunick C., Schwede F., Genieser H.-G., Kleppe R.Doeskeland S. O., Cell Death Dis., e237, 2, 0 - 0 (2011), "Cyclic AMP Induces IPC Leukemia Cell Apoptosis via CRE-and CDK-dependent Bim Transcription"