8-AET-2'-O-Me-cAMP has only poor affinity towards protein kinases A and G and is thus suitable as a ligand in affinity chromatography of cAMP binding proteins that do not require an intact 2'-OH group, such as the exchange protein activated by cyclic AMP (Epac) and certain phosphodiesterases. Detailed technical information available. For reference please compare: Borland et al., Mol. Pharmacol., 69, 374 - 384 (2006).
Cat. No. | A 142 |
CAS number | [634207-89-9] |
Purity | > 98% HPLC |
Salt form | Sodium |
Storage temperature | -20°C / -4°F |
Molecular formula | C₁₃H₁₈N₆O₆PS · Na |
Molecular weight [g/mol] | 440.4 |
Modifications | 8-cAMP, 2'-cAMP |
Target | Epac Activator |
Absorption max [nm] | 279 |
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] | 17000 |