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8-AET-2'-O-Me-cAMP

8- (2- Aminoethylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphate ( 8-AET-2'-O-Me-cAMP ), sodium salt
Cat. No.: A 142
    
CAS No.: [634207-89-9]
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Product Name Price (net) Qty
Cat. No.: A 142-05
Unit: 5 µmol / ~2.2 mg
$248.00

8-AET-2'-O-Me-cAMP has only poor affinity towards protein kinases A and G and is thus suitable as a ligand in affinity chromatography of cAMP binding proteins that do not require an intact 2'-OH group, such as the exchange protein activated by cyclic AMP (Epac) and certain phosphodiesterases. Detailed technical information available. For reference please compare: Borland et al., Mol. Pharmacol., 69, 374 - 384 (2006).

Cat. No. A 142
Patent Information Protected by patent n° EP 02077219.0 and foreign equivalents, exclusively licensed to BIOLOG LSI for research purposes only
CAS number [634207-89-9]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₃H₁₈N₆O₆PS · Na
Molecular weight [g/mol] 440.4
Modifications 8-cAMP, 2'-cAMP
Target Epac Activator
Absorption max [nm] 279
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
  • 1. Borland G., Gupta M., Magiera M. M., Rundell C. J., Fuld S.Yarwood S. J., Mol. Pharmacol., 69, 374 - 384 (2006), "MAP1B-LC1 Enhances Activation of Rap1 by Exchange Protein Activated by Cyclic AMP (EPAC) but not Intracellular Targeting"