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8-ABA-cAMP

8- (4- Aminobutyl)aminoadenosine- 3', 5'- cyclic monophosphate ( 8-ABA-cAMP )
cyclic AMP functionalized for conjugation with markers and dyes or for immobilization
Cat. No.: A 017
    
CAS No.: [82927-68-2]
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Product Name Price (net) Qty
Cat. No.: A 017-05
Unit: 5 µmol / ~2.1 mg
$66.00
Site selective cAMP analogue with preference for site B of R I of cAMP-dependent protein kinase. Can be combined with A-site selective analogues for selective activation of cAK I. Also suitable as a ligand in affinity chromatography and for modification with fluorophores or other markers. Detailed technical information and references available. Reference: Schwede et al., Biochemistry, 39, 8803 - 8812 (2000); Dao et al., J. Biol. Chem., 281, 21500 - 21511 (2006).
Cat. No. A 017
CAS number [82927-68-2]
Purity > 98% HPLC
Storage temperature -20°C / -4°F
Molecular formula C₁₄H₂₂N₇O₆P
Molecular weight [g/mol] 415,4
Modifications 8-cAMP
Target PKA (cAK) Activator
Lipophilicity 0.94
Absorption max [nm] 273
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
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  • 2. Dao K. K., Teigen K., Kopperud R. K., Hodneland E., Schwede F., Christensen A. E., Martinez A.Doeskeland S. O., J. Biol. Chem., 281, 21500 - 21511 (2006), "Epac1 and cAMP-dependent Protein Kinase Holoenzyme Have Similar cAMP Affinity, but Their cAMP Domains Have Distinct Structural Features and Cyclic Nucleotide Recognition"
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  • 6. Schwede F., Christensen A., Liauw S., Hippe T., Kopperud R. K., Jastorff B.Doeskeland S. O., Biochemistry, 39, 8803 - 8812 (2000), "8-Substituted cAMP Analogues Reveal Marked Differences in Adaptability, Hydrogen Bonding, and Charge Accomodation between Homologous Binding Sites (AI/AII and BI/BII) in cAMP Kinase I and II"
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  • 10. Bologa C., Muresan S., Liauw S., Iwitzki F.Chiriac A., Anal. Univ. Timisoara, 2, 27 - 36 (1993), "Quantitative Structure-Activity Study by the MTD-Method for cAMP-Derivatives with Large Substituents in Positions 2 and 8"
  • 11. Oegreid D., Ekanger R., Suva R. H., Miller J. P.Doeskeland S. O., Eur. J. Biochem., 181, 19 - 31 (1989), "Comparison of the Two Classes of Binding Sites ( A and B ) of Type I and Type II Cyclic AMP-dependent Protein Kinases Using Cyclic Nucleotide Analogs"
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