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6-PhEt-ADP

N6- (2- Phenylethyl)adenosine- 5'- O- diphosphate ( 6-PhEt-ADP ), sodium salt

Cat. No.: P 013
    
CAS No.: [681175-76-8]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: P 013-05
Unit: 5 µmol / ~2.7 mg
$252.00

For other salt forms please inquire. Precursor for the preparation of the corresponding radio-labelled triphosphate to be used in the chemical genetics approach (compare: Habelhah et al., J. Biol. Chem., 276, 18090 - 18095 (2001)). The corresponding cold triphosphate is offered as well (Cat. No. P 012). Detailed technical information available. References: Shah et al., Proc. Natl. Acad. Sci. USA, 94, 3565 - 3570 (1997);  Gillespie et al., J. Biol. Chem., 274, 31373 - 31381 (1999); Provance et al., Proc. Natl. Acad. Sci. USA, 101, 1868 - 1873 (2004).

 

Vial containing 500 µl of 10 mM aqueous solution of pH 7.6.

Cat. No. P 013
CAS number [681175-76-8]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution of pH 7.6
Storage temperature -70°C / -94°F
Molecular formula C₁₈H₂₃N₅O₁₀P₂ (free acid)
Molecular weight [g/mol] 531,4 (free acid)
Absorption max [nm] 269
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 20500
  • 1. Zhou Z., Wang X., Li M., Sohma Y., Zou X.Hwang T.-C., J. Physiol., 569, 447 - 457 (2005), "High Affinity ATP/ADP Analogues as New Tools for Studying CFTR Gating"
  • 2. Taylor M. S., Okwuchukwuasanya C., Nickl C. K., Tegge W., Brayden J. E.Dostmann W. R. G., Mol. Pharmacol., 65, 1111 - 1119 (2004), "Inhibition of cGMP-dependent Protein Kinase by the Cell-permeable Peptide DT-2 Reveals a Novel Mechanism of Vasoregulation"
  • 3. Provance D. W., Gourley C. R., Silan C. M., Cameron L. C., Shokat K. M., Goldenring J. R., Shah K., Gillespie P. G.Mercer J. A., Proc. Natl. Acad. Sci., 101, 1868 - 1873 (2004), "Chemical-genetic Inhibition of a Sensitized Mutant Myosin Vb Demonstrates a Role in Peripheral-pericentriolar Membrane Traffic"
  • 4. Habelhah H., Shah K., Huang L., Burlingame A. L., Shokat K. M.Ronai Z., J. Biol. Chem., 276, 18090 - 18095 (2001), "Identification of New JNK Substrate Using ATP Pocket Mutant JNK and a Corresponding ATP Analogue"
  • 5. Gillespie P. G., Gillespie S. K. H., Mercer J. A., Shah K.Shokat K. M., J. Biol. Chem., 274, 31373 - 31381 (1999), "Engineering of the Myosin-Iß Nucleotide-binding Pocket to Create Selective Sensitivity to N6-modified ADP Analogs"
  • 6. Shah K., Liu Y., Deirmengian C.Shokat K. M., Proc. Natl. Acad. Sci. USA, 94, 3565 - 3570 (1997), "Engineering Unnatural Nucleotide Specificity for Rous Sarcoma Virus Tyrosine Kinase to Uniquely Label its Direct Substrates"