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6-Fu-ATP-γ-S

N⁶- Furfuryladenosine- 5'- O- (3- thiotriphosphate) ( 6-Fu-ATP-γ-S ), sodium salt
NTP analogue for chemical genetics
Cat. No.: F 008
    
CAS No.: [1400539-83-4]
Shipping: Dry ice
Product Name Price (net) Qty
Cat. No.: F 008-05
Unit: 5 µmol / ~3 mg
$429.00

For other salt forms or a guaranteed higher purity please inquire.
Analogue useful for specific interaction with modified receptor proteins (chemical genetics approach). 6-Bn-ATP-γ-S (Cat. No. B 072), 6-cPe-ATP-γ-S (Cat. No. C 116), 6-cHe-ATP-γ-S (Cat. No. C 127), 6-(1-MeBu)-ATP-γ-S (Cat. No. M 074), 6-Phe-ATP-γ-S (Cat. No. P 044) and 6-PhEt-ATP-γ-S (Cat. No. P 026) are offered as well. Detailed technical information available. For information on related compounds as well as on the "chemical genetics approach" compare: Allen et al., J. Am. Chem. Soc., 127, 5288 - 5289 (2005); Allen et al., Nature Meth., 4, 511 - 516 (2007). References: Lo & Hollingsworth, Methods Mol. Biol., 745, 135 - 149 (2011); Lourido et al., ACS Chem. Biol., 8, 1155 - 1162 (2013).

 

Vial containing 500 µl of 10 mM aqueous solution of pH 8.5

Cat. No. F 008
CAS number [1400539-83-4]
Purity > 95% HPLC
Salt form Sodium
Appearance 10 mM aqueous solution of pH 8.5
Storage temperature -70°C / -94°F
Molecular formula C₁₅H₂₀N₅O₁₃P₃S (free acid)
Molecular weight [g/mol] 603,3 (free acid)
Absorption max [nm] 267
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 20500
  • 1. Lourido S., Jeschke G. R., Turk B. E.Sibley L. D., ACS Chem. Biol., 8, 1155 - 1162 (2013), "Exploiting the Unique ATP-Binding Pocket of Toxoplasma Calcium-Dependent Protein Kinase 1 to Identify its Substrates"
  • 2. Lo H.-C.Hollingsworth N. M., Methods Mol. Biol., 745, 135 - 149 (2011), "Using the Semi-synthetic Epitope System to Identify Direct Substrates of the Meiosis-specific Budding Yeast Kinase, Mek1"
  • 3. Allen J. J., Li M., Brinkworth C. S., Paulson J. L., Wang D., Hübner A., Chou W.-H., Davis R. J., Burlingame A. L., Messing R. O., Katayama C. D., Hedrick S. M.Shokat K. M., Nature Methods, 4, 511 - 516 (2007), "A Semisynthetic Epitope for Kinase Substrates"
  • 4. Allen J. J., Lazerwith S. E.Shokat K. M., J. Am. Chem. Soc., 127, 5288 - 5289 (2005), "Bio-Orthogonal Affinity Purification of Direct Kinase Substrates"