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6-Bnz-cAMP-AM

N6- Benzoyladenosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester ( 6-Bnz-cAMP-AM )

Cat. No.: B 079
    
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: B 079-01
Unit: 1 µmol / ~0.5 mg
$154.00

Extremely membrane-permeant precursor of the specific PKA agonist 6-Bnz-cAMP (Cat. No. B009). After permeation and metabolic activation by esterases the active compound ist released. 6-Bnz-cAMP-AM does not activate Epac and thus can be used as an Epac-negative control. Reference: Leech et al., Islets, 2, 72 - 81 (2010).

Control reagent for nucleotide AM-ester applications: PO4-AM3, Cat. No. P 030

Cat. No. B 079
CAS number [pending]
Purity > 97 % HPLC for mixture of isomers
Storage temperature -20°C / -4°F
Molecular formula C₂₀H₂₀N₅O₉P
Molecular weight [g/mol] 505,4
Target PKA (cAK) Activator
Absorption max [nm] 279
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 17000
  • 1. Henquin J.-C.Nenquin M., Endocrinol., 0, 0 - 0 (2014), "Activators of PKA and Epac Distinctly Influence Insulin Secretion and Cytosolic Ca2+ in Female Mouse Islets Stimulated by Glucose and Tolbutamide"
  • 2. Dzhura I., Chepurny O. G., Leech C. A., Roe M. W., Dzhura E., Xu X., Lu Y., Schwede F., Genieser H.-G., Smrcka A. V.Holz G. G., Islets, 3, 121 - 128 (2011), "Phospholipase C-epsilon Links Epac2 Activation to the Potentiation of Glucose-stimulated Insulin Secretion from Mouse Islets of Langerhans"
  • 3. Leech C. A., Dzhura I., Chepurny O. G., Schwede F., Genieser H.-G.Holz G. G., Islets, 2, 72 - 81 (2010), "Facilitation of beta-cell KATP Channel Sulfonylurea Sensivity by a cAMP Analog Selective for the cAMP-regulated Guanine Nucleotide Exchange Factor Epac"
  • 4. Dzhura I., Chepurny O. G., Kelley G. G., Leech C. A., Roe M. W., Dzhura E., Afshari P., Malik S., Rindler M. J., Xu X., Lu Y., Smrcka A. V.Holz G. G., J. Physiol., 588, 4871 - 4889 (2010), "EPAC2-dependent Mobilization of Intracellular Ca2+ by Glucagon-like Peptide-1 Receptor Agonist Exendin-4 is Disrupted in Beta-Cells of Phospholipase C-Epsilon Knockout Mice"