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Alternative structural projections:

6-Bnz-8-PIP-cAMP

N6- Benzoyl- 8- piperidinoadenosine- 3', 5'- cyclic monophosphate ( 6-Bnz-8-PIP-cAMP ), sodium salt

Cat. No.: B 055
    
CAS No.: [pending]
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Product Name Price (net) Qty
Cat. No.: B 055-05
Unit: 5 µmol / ~2.7 mg
$205.00
Membrane-permeant activator of protein kinase A which does not activate Epac. Increased metabolic stability. Selects the A site of cAK I and thus can be used for synergistic activation when combined with site B I-selective analogues such as 2-Cl-8-HA-cAMP (Cat. No. C 071), 2-Cl-8-MA-cAMP (Cat. No. C 080), 8-AHA-2-Cl-cAMP (Cat. No. A 199), or 8-ABA-cAMP (Cat. No. A 017). Detailed technical information available. Reference: Huseby et al., Cell Death Dis., 2, e237 (2011).
Cat. No. B 055
CAS number [pending]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₂₂H₂₆N₆O₇P · Na
Molecular weight [g/mol] 540,4
Modifications 8-cAMP
Target PKA (cAK) Activator
Lipophilicity 2.97
Absorption max [nm] 263
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 14000
  • 1. Gausdal G., Wergeland A., Skavland J., Nguyen E., Pendino F., Rouhee N., McCormack E., Herfindal L., Kleppe R., Havemann U., Schwede F., Bruseud O., Gjertsen B. T., Lanotte M., Segal-Bendirdjian E.Doskeland S. O., Cell Death Dis., 4, 0 - 0 (2013), "Cyclic AMP Can Promote APL Progression and Protect Myeloid Leukemia Cells Against Anthracycline-Induced Apoptosis"
  • 2. Huseby S., Gausdal G., Keen T. J., Kjærland E., Krakstad C., Myhren L., Brønstad K., Kunick C., Schwede F., Genieser H.-G., Kleppe R.Doeskeland S. O., Cell Death Dis., e237, 2, 0 - 0 (2011), "Cyclic AMP Induces IPC Leukemia Cell Apoptosis via CRE-and CDK-dependent Bim Transcription"