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6-AH-cAMP-Agarose

N6- (6- Aminohexyl)adenosine- 3', 5'- cyclic monophosphate; immobilized on agarose gel ( 6-AH-cAMP-Agarose )

cyclic AMP immobilized on agarose gel
Cat. No.: A 036
    
CAS No.: [pending]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: A 036-06
Unit: 0.6 ml
$149.00
Cat. No.: A 036-25
Unit: 2.5 ml
$464.00
Cat. No.: A 036-60
Unit: 6 ml
$936.00

The second messenger cyclic AMP immobilized on agarose by an aminohexyl spacer attached to position 6 of the ligand. The gel can be used for affinity chromatography of various cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. This ligand is also offered with a shorter spacer (6-AE-cAMP-Agarose, Cat. No. A 111) and as a PDE-resistant version (Sp-6-AH-cAMPS-Agarose, Cat. No. A 108). Detailed technical information available. Reference: Poteet-Smith et al., J. Biol. Chem., 272, 379 - 388 (1997).

Normally all affinity gels are supplied in pre-packed columns. The free beads without a column are available upon request.

Cat. No. A 036
CAS number [pending]
Storage temperature 4°C / 39°F
Modifications 6-cAMP
  • 1. Hanke S. E., Bertinetti D., Badel A., Schweinsberg S., Genieser H.-G.Herberg F. W., N. Biotechnol., 28, 294 - 301 (2011), "Cyclic Nucleotides as Affinity Tools: Phosphorothioate cAMP Analogues Adress Specific PKA Subproteomes"
  • 2. Hahnefeld C., Diploma work Bochum Germany, 0, 0 - 0 (2000), "Untersuchungen zur Nukleotidbindung von cAMP-abhängigen Proteinkinasen"
  • 3. Poteet-Smith C. E., Shabb J. B., Francis S. H.Corbin J. D., J. Biol. Chem., 272, 379 - 388 (1997), "Identification of Critical Determinants for Autoinhibition in the Pseudosubstrate Region of Type I(Alpha) cAMP-dependent Protein Kinase"
  • 4. Kapphahn M. A.Shabb J. B., Arch. Biochem. Biophys., 348, 347 - 356 (1997), "Contribution of the Carboxyl-Terminal Region of the cAMP-dependent Protein Kinase Type I(Alpha) Regulatory Subunit to Cyclic Nucleotide Interactions"