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Alternative structural projections:

6-AH-cAMP

N⁶- (6- Aminohexyl)adenosine- 3', 5'- cyclic monophosphate ( 6-AH-cAMP )
Functionalized cyclic AMP for immobilization or conjugation with markers and dyes
Cat. No.: A 031
    
CAS No.: [66311-09-9]
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Product Name Price (net) Qty
Cat. No.: A 031-05
Unit: 5 µmol / ~2.1 mg
$99.00
Suitable as a ligand in affinity chromatography of cAMP and cGMP binding proteins and for modification with fluorophores and other markers. Detailed technical information and references available. References: Dills et al., Biochemistry, 15, 3724 - 3731 (1976); Moll et al., J. Neural. Transm., 113, 1015 - 1032 (2006). This ligand is also available with a shorter spacer (6-AE-cAMP; Cat. No. A 096) as well as in a PDE-resistant form (Sp-6-AH-cAMPS, Cat. No. A 089).
Cat. No. A 031
CAS number [66311-09-9]
Purity > 98% HPLC
Salt form Free acid
Storage temperature -20°C / -4°F
Molecular formula C₁₆H₂₅N₆O₆P
Molecular weight [g/mol] 428,4
Target PKA (cAK) Activator
Lipophilicity 1.65
Absorption max [nm] 266
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 16200
  • 1. Schweinsberg S., Moll D., Burghardt N. C., Hahnefeld C., Schwede F., Zimmermann B., Drewianka S., Werner L., Kleinjung F., Genieser H.-G., Schuchhardt J.Herberg F. W., Proteomics, 8, 1212 - 1220 (2008), "Systematic interpretation of cyclic nucleotide binding studies using KinetXBase"
  • 2. Moll D., Prinz A., Gesellchen F., Drewianka S., Zimmermann B.Herberg F. W., J. Neural. Transm., 113, 1015 - 1032 (2006), "Biomolecular Interaction Analysis in Functional Proteomics"
  • 3. Hahnefeld C.Herberg F. W., Abstract of the 13th Protein Kinase Symposium p. 14, 0, 12 - 15 (2002), "cAMP-dependent Protein Kinase: cAMP Analog Screening Using Surface Plasmon Resonance and Fluorescent Methods"
  • 4. Hahnefeld C., Diploma work Bochum Germany, 0, 0 - 0 (2000), "Untersuchungen zur Nukleotidbindung von cAMP-abhängigen Proteinkinasen"
  • 5. Osinski M., Ph.D. Thesis Düsseldorf/Germany, 0, 0 - 0 (2000), "Pharmakologische Ansätze einer Proteinkinase A-Aktivierung zur Hemmung der Mitogenese glatter Gefäßmuskelzellen"
  • 6. Dills W. L., Beavo J. A., Bechtel P. J., Myers K. R., Sakai L. J.Krebs E. G., Biochemistry, 15, 3724 - 3731 (1976), "Binding of Adenosine 3', 5'- Monophosphate Dependent Protein Kinase Regulatory Subunit to Immobilized Cyclic Nucleotide Derivatives"