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5-I-Tu

5- Iodotubercidin ( 5-I-Tu ) / 7- Deaza- 7- iodoadenosine
Cat. No.: I 004
    
CAS No.: [24386-93-4]
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Product Name Price (net) Qty
Cat. No.: I 004-05
Unit: 5 µmol / ~2 mg
$120.00
Potent inhibitor of adenosine kinase and other protein kinases. Detailed technical information available. References: Flückiger-Isler, et al., Biochem. J., 292, 85 - 91 (1993);  Parkinson & Geiger, J. Pharmacol. Exp. Ther., 277, 1397 - 1401 (1996).
This compound is also part of the Ko-Libri compound library (K 001)
Cat. No. I 004
CAS number [24386-93-4]
Purity > 98% HPLC
Storage temperature -20°C / -4°F
Molecular formula C₁₁H₁₃IN₄O₄
Molecular weight [g/mol] 392,2
Absorption max [nm] 283
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 8500
  • 1. Zhang X., Jia D., Liu H., Zhu W., Zhang J., Feng J., Yin J., Hao B., Cui D., Deng Y., Xie D., He L.Li B., PLoS ONE, 8, 0 - 0 (2013), "Identification of 5-Iodotubercidin as a Genotoxic Drug with Anti-Cancer Potential"
  • 2. Long M. C.Parker W. B., Biochem. Pharmacol., 71, 1671 - 1682 (2006), "Structure-activity Relationship for Nucleoside Analogs as Inhibitors or Substrates of Adenosine Kinase from Mycobacterium Tuberculosis I. Modifications to the Adenine Moiety"
  • 3. Kozlowska M., Smolenski R. T., Makarewicz W., Hoffmann C., Jastorff B.Swierczynski J., Toxicol. Lett., 104, 171 - 181 (1999), "ATP Depletion, Purine Riboside Triphosphate Accumulation and Rat Thymocyte Death Induced by Purine Riboside"
  • 4. Parkinson F. E.Geiger J. D., J. Pharmacol. Exp. Ther., 277, 1397 - 1401 (1996), "Effects of Iodotubercidin on Adenosine Kinase Activity and Nucleoside Transport in DDT1 MF-2 Smooth Muscle Cells"
  • 5. Massillon D., Stalmans W., Van de Werve G.Bollen M., Biochem. J., 299, 123 - 128 (1994), "Identification of the Glycogenic Compound 5-iodotubercidin as a General Protein Kinase Inhibitor"
  • 6. Flückiger-Isler R. E.Walter P., Biochem. J., 292, 85 - 91 (1993), "Stimulation of Rat Liver Glycogen Synthesis by the Adenosine Kinase Inhibitor 5-Iodotubercidin"
  • 7. Bergstrom D. E., Brattesani A. J., Ogawa M. K., Reddy P. A., Schweickert M. J., Balzarini J.De Clercq E., J. Med. Chem., 27, 285 - 292 (1984), "Antiviral Activity of C-5 Substituted Tubercidin Analogs"