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5'-dAMPS

2'- Deoxyadenosine- 5'- O- monophosphorothioate ( 5'-dAMPS ), sodium salt
Cat. No.: D 003
    
CAS No.: [64145-26-2]
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Product Name Price (net) Qty
Cat. No.: D 003-05
Unit: 5 µmol / ~1.7 mg
$144.00
Potential substrate, competitive inhibitor or regulator of enzymes that interact with 2'-deoxyadenosine-5'-monophosphate. Can be modified with SH-reactive reporters or linked to structures with SH-groups via a disulfide bond. Detailed technical information available. Reference: Vosberg & Eckstein, J. Biol. Chem., 257, 6595 - 6599 (1982).
Cat. No. D 003
CAS number [64145-26-2]
Purity > 97% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₀H₁₄N₅O₅PS (free acid)
Molecular weight [g/mol] 347,3 (free acid)
Absorption max [nm] 259
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 15200
  • 1. Koziolkiewicz M., Gendaszewska E., Maszewska M., Stein C. A.Stec W. J., Blood, 98, 995 - 1002 (2001), "The Mononucleotide-dependent, Nonantisense Mechanism of Action of Phosphodiester and Phosphorothioate Oligonucleotides Depends upon the Activity of an Ecto-5'-Nucleotidase"
  • 2. Gupta A., DeBrosse C.Benkovic S. J., J. Biol. Chem., 257, 7689 - 7692 (1982), "Template-Primer-dependent Turnover of (Sp)-dATP@S by T4 DNA Polymerase"
  • 3. Vosberg H.-P.Eckstein F., J. Biol. Chem., 257, 6595 - 6599 (1982), "Effect of Deoxynucleoside Phosphorothioates Incorporated in DNA on Cleavage by Restriction Enzymes"
  • 4. Brody R. S.Frey P. A., Biochemistry, 20, 1245 - 1252 (1981), "Unambigous Determination of the Stereochemistry of Nucleotidyl Transfer Catalyzed by DNA Polymerase I from Escherichia coli"
  • 5. Burgers P. M. J.Eckstein F., J. Biol. Chem., 254, 6889 - 6893 (1979), "A Study of the Mechanism of DNA Polymerase I from Escherichia coli with Diastereomeric Phosphorothioate Analogs of Deoxyadenosine Triphosphate"
  • 6. Vosberg H.-P.Eckstein F., Biochemistry, 16, 3633 - 3640 (1977), "Incorporation of Phosphorothioate Groups into fd and phiX174 DNA"