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5-Cl-dC / CldC

5- Chloro- 2'- deoxycytidine ( 5-Cl-dC / CldC )
Cat. No.: C 081
    
CAS No.: [32387-56-7]
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Product Name Price (net) Qty
Cat. No.: C 081-05
Unit: 5 µmol / ~1.3 mg
$110.00
Tumor-selective radiosensitizer and of potential interest in research on chlorine-stressed DNA. Detailed technical information available. Reference: Hale et al., Biochem. Pharmacol., 64, 1493 - 1502 (2002).
Cat. No. C 081
CAS number [32387-56-7]
Purity > 95% HPLC
Storage temperature -20°C / -4°F
Molecular formula C₉H₁₂ClN₃O₄
Molecular weight [g/mol] 261,7
Absorption max [nm] 287
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 7250
  • 1. Stanley N. R., Pattison D. I.Hawkins C. L., Chem. Res. Toxicol., 23, 1293 - 1302 (2010), "Ability of Hypochlorous Acid and N-Chloramines to Chlorinate DNA and Its Constituents"
  • 2. Badouard C., Masuda M., Nishino H., Cadet J., Favier A.Ravanat J.-L., J. Chromatogr., 827, 26 - 31 (2005), "Detection of Chlorinated DNA and RNA Nucleosides by HPLC Coupled to Tandem Mass Spectrometry as Potential Biomarkers of Inflammation"
  • 3. Hale J. A. T., Bigelow J. C., Mathews L. A.McCormack J. J., Biochem. Pharmacol., 64, 1493 - 1502 (2002), "Analytical and Pharmacokinetic Studies with 5-Chloro-2'-Deoxycytidine"
  • 4. Masuda M., Suzuki T., Friesen M. D., Ravanat J.-L., Cadet J., Pignatelli B., Nishino H.Oshima H., J. Biol. Chem., 276, 40486 - 40496 (2001), "Chlorination of Guanosine and Other Nucleosides by Hypochlorous Acid and Myeloperoxidase of Activated Human Neutrophils"