0 Items - $0.00
Categories
A to Z

5,6-DCl-cBIMP

5, 6- Dichlorobenzimidazole riboside- 3', 5'- cyclic monophosphate (5, 6-DCl-cBIMP), sodium salt
Membrane-permeant, ultra-potent PKA agonist
Cat. No.: D 011
    
CAS No.: [129693-10-3]
Shipping: ambient
Product Name Price (net) Qty
Cat. No.: D 011-10
Unit: 10 µmol / ~4 mg
$198.00
For other salt forms or metabolites please inquire. Potent and lipophilic activator of protein kinase A, type I & II. Ten times more active compared to cyclic AMP but rapidly degraded by cyclic nucleotide-dependent phosphodiesterases. Detailed technical information and references available. Reference: Dostmann et al., J. Biol. Chem., 265, 10484 - 10491 (1990).
Cat. No. D 011
CAS number [129693-10-3]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₂H₁₀Cl₂N₂O₆P · Na
Molecular weight [g/mol] 403,1
Modifications 1-cAMP, 2-cAMP, 3-cAMP
Target PKA (cAK) Activator
Lipophilicity 2.82
Absorption max [nm] 254
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 6400
  • 1. Jäger R., Schwede F., Genieser H.-G., Koesling D.Russwurm M., Br. J. Pharmacol., 161, 1645 - 1660 (2010), "Activation of PDE2 and PDE5 cy Specific GAF Ligands: Delayed Activation of PDE5"
  • 2. Walton T. J., Bayliss M. A., Pereira M. L., Games D. E., Genieser H.-G., Brenton A. G., Harris F. M.Newton R. P., Rapid Commun. Mass Spectrom., 12, 449 - 455 (1998), "Fast-atom Bombardment Tandem Mass Spectrometry of Cyclic Nucleotide Analogues Used as Site-selective Activators of Cyclic Nucleotide-dependent Protein Kinases"
  • 3. Bayliss M. A., Pereira L., Games D. E., Brenton A. G., Harris F. M., Newton R. P.Walton T. J., Proc. 2. MS-Pharmaday Siena Italy #C 17-67 - 68, 0, 67 - 68 (1996), "Fast-Atom Bombardment Mass Spectrometry of Site-Specific Effectors of Cyclic Nucleotide Dependent Protein Kinases"
  • 4. Muresan S., Bologa C., Mracec M., Chiriac A., Jastorff B., Simon Z.Naray-Szabo G., J. Mol. Struct., 342, 161 - 171 (1995), "Comparative QSAR Study with Electronic and Steric Parameters for cAMP Derivatives with Large Substituents in Positions 2, 6 and 8"
  • 5. Muresan S., Bologa C., Chiriac A., Jastorff B., Kurunczi L.Simon Z., Quant. Struct.-Act. Relat., 13, 242 - 248 (1994), "Comparative Structure-Affinity Relations by MTD for Binding of Cycloadenosine Monophosphate Derivatives to Protein Kinase Receptors"
  • 6. Bologa C., Muresan S., Liauw S., Iwitzki F.Chiriac A., Anal. Univ. Timisoara, 2, 27 - 36 (1993), "Quantitative Structure-Activity Study by the MTD-Method for cAMP-Derivatives with Large Substituents in Positions 2 and 8"
  • 7. Naß N., Colling C., Cramer M., Genieser H.-G., Butt E., Winkler E., Jaenicke L.Jastorff B., Biochem. J., 285, 129 - 136 (1992), "Mapping of the Epitope/Paratope Interactions of a Monoclonal Antibody Directed Against Adenosine- 3', 5'- monophosphate"
  • 8. Genieser H.-G., Winkler E., Butt E., Zorn M., Schulz S., Iwitzki F., Störmann R., Jastorff B., Doeskeland S. O., Oegreid D., Ruchaud S.Lanotte M., Carbohydr. Res., 234, 217 - 235 (1992), "Derivates of 1-ß-D-Ribofuranosylbenzimidazole 3', 5'-phosphate that Mimic the Actions of Adenosine 3', 5',- phosphate (cAMP) and Guanosine 3', 5'- phosphate (cGMP)"
  • 9. Van Ments-Cohen M., Genieser H.-G., Jastorff B., Van Haastert P. J. M.Schaap P., FEMS Microbiol. Lett., 82, 9 - 14 (1991), "Kinetics and Nucleotide Specificity of a Surface cAMP Binding Site in Dictyostelium discoideum, which is not Down-regulated by cAMP"
  • 10. Dostmann W. R. G., Taylor S. S., Genieser H.-G., Jastorff B., Doeskeland S. O.Oegreid D., J. Biol. Chem., 265, 10484 - 10491 (1990), "Probing the Cyclic Nucleotide Binding Sites of cAMP-Dependent Protein Kinase I and II with Analogs of Adenosine- 3', 5'- Cyclic Phosphorothioates"