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Alternative structural projections:

2'-O-Me-cGMP

2'- O- Methylguanosine- 3', 5'- cyclic monophosphate, sodium salt ( 2'-O-Me-cGMP )
Epac-negative control
Cat. No.: M 036
    
CAS No.: [949909-73-3]
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Product Name Price (net) Qty
Cat. No.: M 036-05
Unit: 5 µmol / ~1.9 mg
$126.00
For other salt forms please inquire. Relatively polar analogue of cyclic GMP which activate neither protein kinase G nor Epac. 2'-O-Me-cGMP can be used as an inactive control in patch clamp applications. Also suitable for receptor mapping studies. The structurally related cAMP-based analogue 2'-O-Me-cAMP is offered as well (Cat. No. M 050). Detailed technical information available. Reference: Strassmaier & Karpen, J. Med. Chem., 50, 4186 - 4194 (2007); Matthiesen & Nielsen, Biochem. J., 423, 401 - 409 (2009); Jäger et al., Br. J. Pharmacol., 161, 1645 - 1660 (2010).
Cat. No. M 036
CAS number [949909-73-3]
Purity > 98% HPLC
Salt form Sodium
Storage temperature -20°C / -4°F
Molecular formula C₁₁H₁₃N₅O₇P · Na
Molecular weight [g/mol] 381,2
Modifications 2'-cGMP
Absorption max [nm] 252
Molar extinction coefficient ε [L·mol⁻¹·cm⁻¹] 13500
  • 1. Kang G., Leech C. A., Chepurny O. G., Coetzee W. A.Holz G. G., J. Physiol., 587, 1307 - 1319 (2008), "Role of the cAMP Sensor Epac as a Determinant of K-ATP Channel ATP-Sensitivity in Human Pancreatic β-Cells and RAT INS-1 Cells"
  • 2. Scott S.-P., Shea P. W.Dryer S. E., Biochem., 46, 9417 - 9431 (2007), "Mapping Ligand Interactions with the Hyperpolarization Activated Cyclic Nucleotide Modulated (HCN) Ion Channel Binding Domain Using a Soluble Construct"
  • 3. Kang G., Chepurny O. G., Malester B., Rindler M. J., Rehmann H., Bos J. L., Schwede F., Coetzee W. A.Holz G. G., J. Physiol.-London, 573, 595 - 609 (2006), "cAMP Sensor Epac as a Determinant of ATP-sensitive Potassium Channel Activity in Human Pancreatic Beta Cells and Rat INS-1 Cells"